Cargando…
Antibiotic Treatment in End Stage Cancer Patients; Advantages and Disadvantages
AIM: In this study our aim was to elucidate whether advanced cancer patients benefit from antibiotic treatment in the last days of life in addition to reviewing the relevant costs and effects. MATERIALS AND METHODS: We reviewed medical records from 100 end-stage cancer patients and their antibiotic...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10064464/ https://www.ncbi.nlm.nih.gov/pubmed/37008074 http://dx.doi.org/10.1177/11769351231161476 |
_version_ | 1785017901180256256 |
---|---|
author | Mamak, Tahmasebi Hadiseh, Hosamirudsari Shirin, Familrashtian Masoud, Parash Mohammadreza, Salehi Mahsa, Abbaszadeh |
author_facet | Mamak, Tahmasebi Hadiseh, Hosamirudsari Shirin, Familrashtian Masoud, Parash Mohammadreza, Salehi Mahsa, Abbaszadeh |
author_sort | Mamak, Tahmasebi |
collection | PubMed |
description | AIM: In this study our aim was to elucidate whether advanced cancer patients benefit from antibiotic treatment in the last days of life in addition to reviewing the relevant costs and effects. MATERIALS AND METHODS: We reviewed medical records from 100 end-stage cancer patients and their antibiotic use during the hospitalization in Imam Khomeini hospital. Patient’s medical records were analyzed retrospectively for cause and periodicity of infections, fever, increase in acute phase proteins, cultures, type and cost of antibiotic. RESULTS: Microorganisms were found in only 29 patients (29%) and the most microorganism among the patients was E. coli (6%). About 78% of the patients had clinical symptoms. The highest dose of antibiotics was related to Ceftriaxone (40.2%) and in the second place was Metronidazole (34.7%) and the lowest dose was related to Levofloxacin, Gentamycin and Colistin (1.4%). Fifty-one patients (71%) did not have any side effects due to antibiotics. The most common side effect of antibiotics among patients was skin rash (12.5%). The average estimated cost for antibiotic use was 7 935 540 Rials (24.4 dollars). CONCLUSION: Prescription of antibiotics was not effective in symptom control in advanced cancer patients. The cost of using antibiotics during hospitalization is very high and also the risk of developing resistant pathogens during admission should be considered. Antibiotic side effects also occur in patients, causing more harm to the patient at the end of life. Therefore, the benefits of antibiotic advice in this time is less than its negative effects. |
format | Online Article Text |
id | pubmed-10064464 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-100644642023-04-01 Antibiotic Treatment in End Stage Cancer Patients; Advantages and Disadvantages Mamak, Tahmasebi Hadiseh, Hosamirudsari Shirin, Familrashtian Masoud, Parash Mohammadreza, Salehi Mahsa, Abbaszadeh Cancer Inform Original Research AIM: In this study our aim was to elucidate whether advanced cancer patients benefit from antibiotic treatment in the last days of life in addition to reviewing the relevant costs and effects. MATERIALS AND METHODS: We reviewed medical records from 100 end-stage cancer patients and their antibiotic use during the hospitalization in Imam Khomeini hospital. Patient’s medical records were analyzed retrospectively for cause and periodicity of infections, fever, increase in acute phase proteins, cultures, type and cost of antibiotic. RESULTS: Microorganisms were found in only 29 patients (29%) and the most microorganism among the patients was E. coli (6%). About 78% of the patients had clinical symptoms. The highest dose of antibiotics was related to Ceftriaxone (40.2%) and in the second place was Metronidazole (34.7%) and the lowest dose was related to Levofloxacin, Gentamycin and Colistin (1.4%). Fifty-one patients (71%) did not have any side effects due to antibiotics. The most common side effect of antibiotics among patients was skin rash (12.5%). The average estimated cost for antibiotic use was 7 935 540 Rials (24.4 dollars). CONCLUSION: Prescription of antibiotics was not effective in symptom control in advanced cancer patients. The cost of using antibiotics during hospitalization is very high and also the risk of developing resistant pathogens during admission should be considered. Antibiotic side effects also occur in patients, causing more harm to the patient at the end of life. Therefore, the benefits of antibiotic advice in this time is less than its negative effects. SAGE Publications 2023-03-29 /pmc/articles/PMC10064464/ /pubmed/37008074 http://dx.doi.org/10.1177/11769351231161476 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Mamak, Tahmasebi Hadiseh, Hosamirudsari Shirin, Familrashtian Masoud, Parash Mohammadreza, Salehi Mahsa, Abbaszadeh Antibiotic Treatment in End Stage Cancer Patients; Advantages and Disadvantages |
title | Antibiotic Treatment in End Stage Cancer Patients; Advantages and Disadvantages |
title_full | Antibiotic Treatment in End Stage Cancer Patients; Advantages and Disadvantages |
title_fullStr | Antibiotic Treatment in End Stage Cancer Patients; Advantages and Disadvantages |
title_full_unstemmed | Antibiotic Treatment in End Stage Cancer Patients; Advantages and Disadvantages |
title_short | Antibiotic Treatment in End Stage Cancer Patients; Advantages and Disadvantages |
title_sort | antibiotic treatment in end stage cancer patients; advantages and disadvantages |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10064464/ https://www.ncbi.nlm.nih.gov/pubmed/37008074 http://dx.doi.org/10.1177/11769351231161476 |
work_keys_str_mv | AT mamaktahmasebi antibiotictreatmentinendstagecancerpatientsadvantagesanddisadvantages AT hadisehhosamirudsari antibiotictreatmentinendstagecancerpatientsadvantagesanddisadvantages AT shirinfamilrashtian antibiotictreatmentinendstagecancerpatientsadvantagesanddisadvantages AT masoudparash antibiotictreatmentinendstagecancerpatientsadvantagesanddisadvantages AT mohammadrezasalehi antibiotictreatmentinendstagecancerpatientsadvantagesanddisadvantages AT mahsaabbaszadeh antibiotictreatmentinendstagecancerpatientsadvantagesanddisadvantages |