Relaxin-encapsulated polymeric metformin nanoparticles remodel tumor immune microenvironment by reducing CAFs for efficient triple-negative breast cancer immunotherapy

Cancer-associated fibroblasts (CAFs) are one of the most abundant stromal cells in the tumor microenvironment which mediate desmoplastic response and are the primary driver for an immunosuppressive microenvironment, leading to the failure of triple-negative breast cancer (TNBC) immunotherapy. Theref...

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Detalles Bibliográficos
Autores principales: Zhang, Hongyan, Chen, Liying, Zhao, Yue, Luo, Ningchao, Shi, Jingbin, Xu, Shujun, Ma, Lisha, Wang, Menglin, Gu, Mancang, Mu, Chaofeng, Xiong, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shenyang Pharmaceutical University 2023
Materias:
Original Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10064789/
https://www.ncbi.nlm.nih.gov/pubmed/37008735
http://dx.doi.org/10.1016/j.ajps.2023.100796

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