Crosstalk between triple negative breast cancer and microenvironment

Although many advances have been made in the treatment of breast cancer, for the triple negative breast cancer (TNBC) these therapies have not significantly increased overall survival. Tumor microenvironment (TME) plays an essential role to develop and control TNBC progression. Many preclinical and...

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Detalles Bibliográficos
Autores principales: Smrekar, Karly, Belyakov, Artem, Jin, Kideok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10064880/
https://www.ncbi.nlm.nih.gov/pubmed/36999995
http://dx.doi.org/10.18632/oncotarget.28397
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author Smrekar, Karly
Belyakov, Artem
Jin, Kideok
author_facet Smrekar, Karly
Belyakov, Artem
Jin, Kideok
author_sort Smrekar, Karly
collection PubMed
description Although many advances have been made in the treatment of breast cancer, for the triple negative breast cancer (TNBC) these therapies have not significantly increased overall survival. Tumor microenvironment (TME) plays an essential role to develop and control TNBC progression. Many preclinical and clinical studies are ongoing to treat patients with TNBC disease, but the effective therapies are currently not available. Here, we have reviewed recent progress in understanding of TNBC and advance in defining mechanisms of TNBC therapies and potential therapeutic strategies to overcome TNBC.
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spelling pubmed-100648802023-04-01 Crosstalk between triple negative breast cancer and microenvironment Smrekar, Karly Belyakov, Artem Jin, Kideok Oncotarget Review Although many advances have been made in the treatment of breast cancer, for the triple negative breast cancer (TNBC) these therapies have not significantly increased overall survival. Tumor microenvironment (TME) plays an essential role to develop and control TNBC progression. Many preclinical and clinical studies are ongoing to treat patients with TNBC disease, but the effective therapies are currently not available. Here, we have reviewed recent progress in understanding of TNBC and advance in defining mechanisms of TNBC therapies and potential therapeutic strategies to overcome TNBC. Impact Journals LLC 2023-03-31 /pmc/articles/PMC10064880/ /pubmed/36999995 http://dx.doi.org/10.18632/oncotarget.28397 Text en Copyright: © 2023 Smrekar et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Smrekar, Karly
Belyakov, Artem
Jin, Kideok
Crosstalk between triple negative breast cancer and microenvironment
title Crosstalk between triple negative breast cancer and microenvironment
title_full Crosstalk between triple negative breast cancer and microenvironment
title_fullStr Crosstalk between triple negative breast cancer and microenvironment
title_full_unstemmed Crosstalk between triple negative breast cancer and microenvironment
title_short Crosstalk between triple negative breast cancer and microenvironment
title_sort crosstalk between triple negative breast cancer and microenvironment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10064880/
https://www.ncbi.nlm.nih.gov/pubmed/36999995
http://dx.doi.org/10.18632/oncotarget.28397
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