Bispecific antibodies combine breadth, potency, and avidity of parental antibodies to neutralize sarbecoviruses

SARS-CoV-2 variants evade current monoclonal antibody therapies. Bispecific antibodies (bsAbs) combine the specificities of two distinct antibodies taking advantage of the avidity and synergy provided by targeting different epitopes. Here we used controlled Fab-arm exchange to produce bsAbs that neu...

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Detalles Bibliográficos
Autores principales: Radić, Laura, Sliepen, Kwinten, Yin, Victor, Brinkkemper, Mitch, Capella-Pujol, Joan, Schriek, Angela I., Torres, Jonathan L., Bangaru, Sandhya, Burger, Judith A., Poniman, Meliawati, Bontjer, Ilja, Bouhuijs, Joey H., Gideonse, David, Eggink, Dirk, Ward, Andrew B., Heck, Albert J.R., Van Gils, Marit J., Sanders, Rogier W., Schinkel, Janke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065043/
https://www.ncbi.nlm.nih.gov/pubmed/37063468
http://dx.doi.org/10.1016/j.isci.2023.106540

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