Kras oncogene ablation prevents resistance in advanced lung adenocarcinomas

KRAS(G12C) inhibitors have revolutionized the clinical management of patients with KRAS(G12C)-mutant lung adenocarcinoma. However, patient exposure to these inhibitors leads to the rapid onset of resistance. In this study, we have used genetically engineered mice to compare the therapeutic efficacy...

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Detalles Bibliográficos
Autores principales: Salmón, Marina, Álvarez-Díaz, Ruth, Fustero-Torre, Coral, Brehey, Oksana, Lechuga, Carmen G., Sanclemente, Manuel, Fernández-García, Fernando, López-García, Alejandra, Martín-Guijarro, María Carmen, Rodríguez-Perales, Sandra, Bousquet-Mur, Emily, Morales-Cacho, Lucía, Mulero, Francisca, Al-Shahrour, Fátima, Martínez, Lola, Domínguez, Orlando, Caleiras, Eduardo, Ortega, Sagrario, Guerra, Carmen, Musteanu, Monica, Drosten, Matthias, Barbacid, Mariano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065067/
https://www.ncbi.nlm.nih.gov/pubmed/36928090
http://dx.doi.org/10.1172/JCI164413

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