Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination

Multiple sclerosis (MS) is a progressive inflammatory demyelinating disease of the CNS. Increasing evidence suggests that vulnerable neurons in MS exhibit fatal metabolic exhaustion over time, a phenomenon hypothesized to be caused by chronic hyperexcitability. Axonal Kv7 (outward-rectifying) and ol...

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Detalles Bibliográficos
Autores principales: Kapell, Hannah, Fazio, Luca, Dyckow, Julia, Schwarz, Sophia, Cruz-Herranz, Andrés, Mayer, Christina, Campos, Joaquin, D’Este, Elisa, Möbius, Wiebke, Cordano, Christian, Pröbstel, Anne-Katrin, Gharagozloo, Marjan, Zulji, Amel, Narayanan Naik, Venu, Delank, Anna, Cerina, Manuela, Müntefering, Thomas, Lerma-Martin, Celia, Sonner, Jana K., Sin, Jung Hyung, Disse, Paul, Rychlik, Nicole, Sabeur, Khalida, Chavali, Manideep, Srivastava, Rajneesh, Heidenreich, Matthias, Fitzgerald, Kathryn C., Seebohm, Guiscard, Stadelmann, Christine, Hemmer, Bernhard, Platten, Michael, Jentsch, Thomas J., Engelhardt, Maren, Budde, Thomas, Nave, Klaus-Armin, Calabresi, Peter A., Friese, Manuel A., Green, Ari J., Acuna, Claudio, Rowitch, David H., Meuth, Sven G., Schirmer, Lucas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065072/
https://www.ncbi.nlm.nih.gov/pubmed/36719741
http://dx.doi.org/10.1172/JCI164223

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