EMT-activated secretory and endocytic vesicular trafficking programs underlie a vulnerability to PI4K2A antagonism in lung cancer

Hypersecretory malignant cells underlie therapeutic resistance, metastasis, and poor clinical outcomes. However, the molecular basis for malignant hypersecretion remains obscure. Here, we showed that epithelial-mesenchymal transition (EMT) initiates exocytic and endocytic vesicular trafficking progr...

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Detalles Bibliográficos
Autores principales: Tan, Xiaochao, Xiao, Guan-Yu, Wang, Shike, Shi, Lei, Zhao, Yanbin, Liu, Xin, Yu, Jiang, Russell, William K., Creighton, Chad J., Kurie, Jonathan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065074/
https://www.ncbi.nlm.nih.gov/pubmed/36757799
http://dx.doi.org/10.1172/JCI165863

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