IL-1 receptor–associated kinase-3 acts as an immune checkpoint in myeloid cells to limit cancer immunotherapy

Inflammatory mediators released by cancer cells promote the induction of immune suppression and tolerance in myeloid cells. IL-1 receptor–associated kinase-3 (IRAK3) is a pseudokinase that inhibits IL-1/TLR signaling, but its role in patients treated with immune checkpoint blockade (ICB) therapy rem...

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Detalles Bibliográficos
Autores principales: Tunalı, Gürcan, Rúbies Bedós, Marta, Nagarajan, Divya, Fridh, Patrik, Papakyriacou, Irineos, Mao, Yumeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065081/
https://www.ncbi.nlm.nih.gov/pubmed/36757800
http://dx.doi.org/10.1172/JCI161084

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