Na(V)1.6 dysregulation within myocardial T-tubules by D96V calmodulin enhances proarrhythmic sodium and calcium mishandling

Calmodulin (CaM) plays critical roles in cardiomyocytes, regulating Na(+) (Na(V)) and L-type Ca(2+) channels (LTCCs). LTCC dysregulation by mutant CaMs has been implicated in action potential duration (APD) prolongation and arrhythmogenic long QT (LQT) syndrome. Intriguingly, D96V-CaM prolongs APD m...

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Detalles Bibliográficos
Autores principales: Tarasov, Mikhail, Struckman, Heather L., Olgar, Yusuf, Miller, Alec, Demirtas, Mustafa, Bogdanov, Vladimir, Terentyeva, Radmila, Soltisz, Andrew M., Meng, Xiaolei, Min, Dennison, Sakuta, Galina, Dunlap, Izabella, Duran, Antonia D., Foster, Mark P., Davis, Jonathan P., Terentyev, Dmitry, Györke, Sándor, Veeraraghavan, Rengasayee, Radwański, Przemysław B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065082/
https://www.ncbi.nlm.nih.gov/pubmed/36821382
http://dx.doi.org/10.1172/JCI152071

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