Decitabine priming increases anti–PD-1 antitumor efficacy by promoting CD8(+) progenitor exhausted T cell expansion in tumor models

CD8(+) exhausted T cells (T(ex)) are heterogeneous. PD-1 inhibitors reinvigorate progenitor T(ex), which subsequently differentiate into irresponsive terminal T(ex). The ability to maintain a capacity for durable proliferation of progenitor T(ex) is important, but the mechanism remains unclear. Here...

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Detalles Bibliográficos
Autores principales: Li, Xiang, Li, Yaru, Dong, Liang, Chang, Yixin, Zhang, Xingying, Wang, Chunmeng, Chen, Meixia, Bo, Xiaochen, Chen, Hebing, Han, Weidong, Nie, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065084/
https://www.ncbi.nlm.nih.gov/pubmed/36853831
http://dx.doi.org/10.1172/JCI165673

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