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Multicomponent synthesis of chromophores – The one-pot approach to functional π-systems

Multicomponent reactions, conducted in a domino, sequential or consecutive fashion, have not only considerably enhanced synthetic efficiency as one-pot methodology, but they have also become an enabling tool for interdisciplinary research. The highly diversity-oriented nature of the synthetic concep...

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Detalles Bibliográficos
Autores principales: Brandner, Larissa, Müller, Thomas J. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065161/
https://www.ncbi.nlm.nih.gov/pubmed/37007054
http://dx.doi.org/10.3389/fchem.2023.1124209
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author Brandner, Larissa
Müller, Thomas J. J.
author_facet Brandner, Larissa
Müller, Thomas J. J.
author_sort Brandner, Larissa
collection PubMed
description Multicomponent reactions, conducted in a domino, sequential or consecutive fashion, have not only considerably enhanced synthetic efficiency as one-pot methodology, but they have also become an enabling tool for interdisciplinary research. The highly diversity-oriented nature of the synthetic concept allows accessing huge structural and functional space. Already some decades ago this has been recognized for life sciences, in particular, lead finding and exploration in pharma and agricultural chemistry. The quest for novel functional materials has also opened the field for diversity-oriented syntheses of functional π-systems, i.e. dyes for photonic and electronic applications based on their electronic properties. This review summarizes recent developments in MCR syntheses of functional chromophores highlighting syntheses following either the framework forming scaffold approach by establishing connectivity between chromophores or the chromogenic chromophore approach by de novo formation of chromophore of interest. Both approaches warrant rapid access to molecular functional π-systems, i.e. chromophores, fluorophores, and electrophores for various applications.
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spelling pubmed-100651612023-04-01 Multicomponent synthesis of chromophores – The one-pot approach to functional π-systems Brandner, Larissa Müller, Thomas J. J. Front Chem Chemistry Multicomponent reactions, conducted in a domino, sequential or consecutive fashion, have not only considerably enhanced synthetic efficiency as one-pot methodology, but they have also become an enabling tool for interdisciplinary research. The highly diversity-oriented nature of the synthetic concept allows accessing huge structural and functional space. Already some decades ago this has been recognized for life sciences, in particular, lead finding and exploration in pharma and agricultural chemistry. The quest for novel functional materials has also opened the field for diversity-oriented syntheses of functional π-systems, i.e. dyes for photonic and electronic applications based on their electronic properties. This review summarizes recent developments in MCR syntheses of functional chromophores highlighting syntheses following either the framework forming scaffold approach by establishing connectivity between chromophores or the chromogenic chromophore approach by de novo formation of chromophore of interest. Both approaches warrant rapid access to molecular functional π-systems, i.e. chromophores, fluorophores, and electrophores for various applications. Frontiers Media S.A. 2023-03-17 /pmc/articles/PMC10065161/ /pubmed/37007054 http://dx.doi.org/10.3389/fchem.2023.1124209 Text en Copyright © 2023 Brandner and Müller. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Brandner, Larissa
Müller, Thomas J. J.
Multicomponent synthesis of chromophores – The one-pot approach to functional π-systems
title Multicomponent synthesis of chromophores – The one-pot approach to functional π-systems
title_full Multicomponent synthesis of chromophores – The one-pot approach to functional π-systems
title_fullStr Multicomponent synthesis of chromophores – The one-pot approach to functional π-systems
title_full_unstemmed Multicomponent synthesis of chromophores – The one-pot approach to functional π-systems
title_short Multicomponent synthesis of chromophores – The one-pot approach to functional π-systems
title_sort multicomponent synthesis of chromophores – the one-pot approach to functional π-systems
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065161/
https://www.ncbi.nlm.nih.gov/pubmed/37007054
http://dx.doi.org/10.3389/fchem.2023.1124209
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