Penile metastasis from prostate cancer misdiagnosed as Peyronie disease: a case report

INTRODUCTION: Penile metastases from prostate cancer are rare, and patients’ prognosis and survival rates are low. Conservative treatment is usually recommended for such patients with an emphasis on improving their quality of life. AIMS: The aims were to raise awareness of penile metastasis from prostate cancer and Peyronie disease among physicians and other health care professionals, as well as to provide a useful experience for future diagnosis and treatment. METHODS: The current case report is based on patient self-report and a literature review. Written informed consent was obtained from the patient. RESULTS: We report the case of a 68-year-old man who was admitted with a complaint of urinary retention. Preoperative examination and ancillary tests showed a 2.0-cm-long hard nodule palpable on the dorsal aspect of the penile root, which was misdiagnosed as Peyronie disease. However, a biopsy of the penile scleroma was performed, and the final pathology finding confirmed the diagnosis of penile metastasis from prostate cancer. The patient opted for continuous androgen deprivation therapy (abiraterone) and systemic chemotherapy (docetaxel and cisplatin). He was treated for 2 cycles and had no specific discomfort during chemotherapy, except for significant gastrointestinal reactions, hypocellularity, and hair loss symptoms. CONCLUSION: This report describes a rare case of penile metastasis from prostate cancer, which was initially misdiagnosed as Peyronie disease, indicating that clinicians need to improve their understanding and discrimination of this disease.