Cargando…

Enhanced therapeutic window for antimicrobial Pept-ins by investigating their structure-activity relationship

The overconsumption and inappropriate use of antibiotics is escalating antibiotic resistance development, which is now one of the 10 top threats to global health. Introducing antibiotics with a novel mode of action into clinical use is urgently needed to address this issue. Deliberately inducing agg...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Guiqin, Khodaparast, Laleh, Khodaparast, Ladan, De Vleeschouwer, Matthias, Louros, Nikolaos, Gallardo, Rodrigo, Yi, Pengpeng, Rousseau, Frederic, Schymkowitz, Joost
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065276/ https://www.ncbi.nlm.nih.gov/pubmed/37000776 http://dx.doi.org/10.1371/journal.pone.0283674

Ejemplares similares

Synthetic Pept-Ins as a Generic Amyloid-Like Aggregation-Based Platform for In Vivo PET Imaging of Intracellular Targets
por: Siemons, Maxime, et al.
Publicado: (2021)

Bacterial Protein Homeostasis Disruption as a Therapeutic Intervention
por: Khodaparast, Laleh, et al.
Publicado: (2021)

Exploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding
por: Khodaparast, Ladan, et al.
Publicado: (2023)

The Dynamic Transition of Persistence toward the Viable but Nonculturable State during Stationary Phase Is Driven by Protein Aggregation
por: Dewachter, Liselot, et al.
Publicado: (2021)

Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities
por: Louros, Nikolaos, et al.
Publicado: (2020)

Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis
por: Khodaparast, Ladan, et al.
Publicado: (2018)

Gene Erosion Can Lead to Gain-of-Function Alleles That Contribute to Bacterial Fitness
por: Mortier, Julien, et al.
Publicado: (2021)

Erratum for Mortier and Gayán et al., “Gene Erosion Can Lead to Gain-of-Function Alleles That Contribute to Bacterial Fitness”
por: Mortier, Julien, et al.
Publicado: (2021)

WALTZ-DB 2.0: an updated database containing structural information of experimentally determined amyloid-forming peptides
por: Louros, Nikolaos, et al.
Publicado: (2020)

Reverse engineering synthetic antiviral amyloids
por: Michiels, Emiel, et al.
Publicado: (2020)

Author Correction: Reverse engineering synthetic antiviral amyloids
por: Michiels, Emiel, et al.
Publicado: (2023)

Exploiting the intrinsic misfolding propensity of the KRAS oncoprotein
por: Janssen, Kobe, et al.
Publicado: (2023)

Entropic Bristles Tune the Seeding Efficiency of Prion-Nucleating Fragments
por: Michiels, Emiel, et al.
Publicado: (2020)

Development of antiseptic adaptation and cross-adapatation in selected oral pathogens in vitro
por: Verspecht, Tim, et al.
Publicado: (2019)

Pituitary adenylate cyclase-activating polypeptide (PACAP) in zebrafish models of nephrotic syndrome
por: Eneman, Benedicte, et al.
Publicado: (2017)

The Possible Role of Staphylococcus epidermidis LPxTG Surface Protein SesC in Biofilm Formation
por: Khodaparast, Laleh, et al.
Publicado: (2016)

Heating Wheat Gluten Promotes the Formation of Amyloid-like Fibrils
por: Monge-Morera, Margarita, et al.
Publicado: (2021)

USP18 Sensitivity of Peptide Transporters PEPT1 and PEPT2
por: Warsi, Jamshed, et al.
Publicado: (2015)

Using structural bioinformatics to investigate the impact of non synonymous SNPs and disease mutations: scope and limitations
por: Reumers, Joke, et al.
Publicado: (2009)

Thermodynamic and Evolutionary Coupling between the Native and Amyloid State of Globular Proteins
por: Langenberg, Tobias, et al.
Publicado: (2020)

Accurate Prediction of DnaK-Peptide Binding via Homology Modelling and Experimental Data
por: Van Durme, Joost, et al.
Publicado: (2009)

Targeting S100B with Peptides Encoding Intrinsic Aggregation-Prone Sequence Segments
por: Cristóvão, Joana S., et al.
Publicado: (2021)

Cystinosis (ctns) zebrafish mutant shows pronephric glomerular and tubular dysfunction
por: Elmonem, Mohamed A., et al.
Publicado: (2017)

Standard method for performing positron emission particle tracking (PEPT) measurements of froth flotation at PEPT Cape Town
por: Cole, Katie, et al.
Publicado: (2022)

Peptide transporter structure reveals binding and action mechanism of a potent PEPT1 and PEPT2 inhibitor
por: Stauffer, Mirko, et al.
Publicado: (2022)

Crystal Structures of the Extracellular Domain from PepT1 and PepT2 Provide Novel Insights into Mammalian Peptide Transport
por: Beale, John H., et al.
Publicado: (2015)

Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes
por: Killer, Maxime, et al.
Publicado: (2021)

The culprit behind amyloid beta peptide related neurotoxicity in Alzheimer's disease: oligomer size or conformation?
por: Broersen, Kerensa, et al.
Publicado: (2010)

Transcellular Spreading of Tau in Tauopathies
por: Demaegd, Koen, et al.
Publicado: (2018)

Mechanisms and therapeutic potential of interactions between human amyloids and viruses
por: Michiels, Emiel, et al.
Publicado: (2020)

Mapping the sequence specificity of heterotypic amyloid interactions enables the identification of aggregation modifiers
por: Louros, Nikolaos, et al.
Publicado: (2022)

Anticonvulsant Activity of Hydroalcoholic Extract and Aqueous Fraction of Ebenus stellata in Mice
por: Khodaparast, Ayeh, et al.
Publicado: (2012)

What Makes a Protein Sequence a Prion?
por: Sabate, Raimon, et al.
Publicado: (2015)

Differential proteostatic regulation of insoluble and abundant proteins
por: Ramakrishnan, Reshmi, et al.
Publicado: (2019)

Screening of the anticonvulsant activity of some plants from Fabaceae family in experimental seizure models in mice
por: Sayyah, M., et al.
Publicado: (2011)

Central serous chorioretinopathy following ingestion of sildenafil citrate
por: Mohammadpour, Mehrdad, et al.
Publicado: (2019)

A Two-Step Approach for Diagnosing Glutamate Dehydrogenase Genes by Conventional Polymerase Chain Reaction from Clostridium difficile Isolates
por: Khodaparast, Sepideh, et al.
Publicado: (2019)

Regulation profile of the intestinal peptide transporter 1 (PepT1)
por: Wang, Chun-Yang, et al.
Publicado: (2017)

PEPT1-mediated prodrug strategy for oral delivery of peramivir
por: Sun, Yongbing, et al.
Publicado: (2018)

Critical Role of PepT1 in Promoting Colitis-Associated Cancer and Therapeutic Benefits of the Anti-inflammatory PepT1-Mediated Tripeptide KPV in a Murine Model
por: Viennois, Emilie, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_nndvkhn3j7u8d6hrj0m1rvmjd6