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Ultrasonographic differentiation and Ultrasound-based management of partially cystic thyroid nodules

OBJECTIVE: To determine sonographic features of malignancy in partially cystic thyroid nodules and assess the diagnostic efficacy of these features for differentiating between benign and malignant lesions in the nodules with indeterminate cytology. SUBJECTS AND METHODS: From January 2016 to December...

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Autores principales: Liu, Yanjun, Zhao, Yanru, Fu, Jiao, Liu, Shu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Endocrinologia e Metabologia 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065333/
https://www.ncbi.nlm.nih.gov/pubmed/33939910
http://dx.doi.org/10.20945/2359-3997000000367
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author Liu, Yanjun
Zhao, Yanru
Fu, Jiao
Liu, Shu
author_facet Liu, Yanjun
Zhao, Yanru
Fu, Jiao
Liu, Shu
author_sort Liu, Yanjun
collection PubMed
description OBJECTIVE: To determine sonographic features of malignancy in partially cystic thyroid nodules and assess the diagnostic efficacy of these features for differentiating between benign and malignant lesions in the nodules with indeterminate cytology. SUBJECTS AND METHODS: From January 2016 to December 2017, a total of 91 patients with 94 partially cystic thyroid nodules who had undergone ultrasound-guided fine-needle aspiration biopsy and thyroid surgery in our hospital were included in this study. The sonographic features of the thyroid nodules were analyzed to identify the predictive features of malignancy and assess the diagnostic efficacy of these features. RESULTS: The features of hypoechogenicity, microcalcification, composition, and an eccentric solid component with an acute angle had statistically significant associations with malignant nodule (p<005) by univariable analysis. Binary logistic regression analysis showed that microcalcification and hypoechogenicity were significantly associated with malignancy. Using the combination of microcalcification, hypoechogenicity, and a solid component comprising of greater than or equal to 50% of the total volume, the diagnostic sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were 97.6%, 32.7%, 53.9%, and 94.4%, respectively. In these nodules with indeterminate cytology, this combination also exhibited a high sensitivity of 92.3% and an NPV of 83.3%. CONCLUSION: This study demonstrated that microcalcification and hypoechogenicity were independently associated with malignancy in partially cystic thyroid nodules. The combination of microcalcification, hypoechogenicity, and a solid portion that is greater than or equal to 50% of the total volume will help guide clinical decisions in mixed cystic solid nodules.
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spelling pubmed-100653332023-04-01 Ultrasonographic differentiation and Ultrasound-based management of partially cystic thyroid nodules Liu, Yanjun Zhao, Yanru Fu, Jiao Liu, Shu Arch Endocrinol Metab Original Article OBJECTIVE: To determine sonographic features of malignancy in partially cystic thyroid nodules and assess the diagnostic efficacy of these features for differentiating between benign and malignant lesions in the nodules with indeterminate cytology. SUBJECTS AND METHODS: From January 2016 to December 2017, a total of 91 patients with 94 partially cystic thyroid nodules who had undergone ultrasound-guided fine-needle aspiration biopsy and thyroid surgery in our hospital were included in this study. The sonographic features of the thyroid nodules were analyzed to identify the predictive features of malignancy and assess the diagnostic efficacy of these features. RESULTS: The features of hypoechogenicity, microcalcification, composition, and an eccentric solid component with an acute angle had statistically significant associations with malignant nodule (p<005) by univariable analysis. Binary logistic regression analysis showed that microcalcification and hypoechogenicity were significantly associated with malignancy. Using the combination of microcalcification, hypoechogenicity, and a solid component comprising of greater than or equal to 50% of the total volume, the diagnostic sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were 97.6%, 32.7%, 53.9%, and 94.4%, respectively. In these nodules with indeterminate cytology, this combination also exhibited a high sensitivity of 92.3% and an NPV of 83.3%. CONCLUSION: This study demonstrated that microcalcification and hypoechogenicity were independently associated with malignancy in partially cystic thyroid nodules. The combination of microcalcification, hypoechogenicity, and a solid portion that is greater than or equal to 50% of the total volume will help guide clinical decisions in mixed cystic solid nodules. Sociedade Brasileira de Endocrinologia e Metabologia 2021-04-29 /pmc/articles/PMC10065333/ /pubmed/33939910 http://dx.doi.org/10.20945/2359-3997000000367 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Liu, Yanjun
Zhao, Yanru
Fu, Jiao
Liu, Shu
Ultrasonographic differentiation and Ultrasound-based management of partially cystic thyroid nodules
title Ultrasonographic differentiation and Ultrasound-based management of partially cystic thyroid nodules
title_full Ultrasonographic differentiation and Ultrasound-based management of partially cystic thyroid nodules
title_fullStr Ultrasonographic differentiation and Ultrasound-based management of partially cystic thyroid nodules
title_full_unstemmed Ultrasonographic differentiation and Ultrasound-based management of partially cystic thyroid nodules
title_short Ultrasonographic differentiation and Ultrasound-based management of partially cystic thyroid nodules
title_sort ultrasonographic differentiation and ultrasound-based management of partially cystic thyroid nodules
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065333/
https://www.ncbi.nlm.nih.gov/pubmed/33939910
http://dx.doi.org/10.20945/2359-3997000000367
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