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Factors associated to serum paraoxonase 1 activity in patients with cardiovascular disease

OBJECTIVES: Paraoxonase 1 (PON1) is an enzyme that has antioxidant potential, which confers a protective effect against the atherosclerotic process. However, studies associating genetics, dietary patterns and PON1 activity in individuals with cardiovascular disease (CVD) are scarce. Thus, the aim of...

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Autores principales: Longo, Aline, Veiga, Gabriel Barreto, Cousen, Maria Isabel Schiavon, Karpinski, Caroline, Schneider, Augusto, Weber, Bernardete, Bertoldi, Eduardo Gehling, Borges, Lucia Rota, Bertacco, Renata Torres Abib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Endocrinologia e Metabologia 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065381/
https://www.ncbi.nlm.nih.gov/pubmed/33844899
http://dx.doi.org/10.20945/2359-3997000000354
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author Longo, Aline
Veiga, Gabriel Barreto
Cousen, Maria Isabel Schiavon
Karpinski, Caroline
Schneider, Augusto
Weber, Bernardete
Bertoldi, Eduardo Gehling
Borges, Lucia Rota
Bertacco, Renata Torres Abib
author_facet Longo, Aline
Veiga, Gabriel Barreto
Cousen, Maria Isabel Schiavon
Karpinski, Caroline
Schneider, Augusto
Weber, Bernardete
Bertoldi, Eduardo Gehling
Borges, Lucia Rota
Bertacco, Renata Torres Abib
author_sort Longo, Aline
collection PubMed
description OBJECTIVES: Paraoxonase 1 (PON1) is an enzyme that has antioxidant potential, which confers a protective effect against the atherosclerotic process. However, studies associating genetics, dietary patterns and PON1 activity in individuals with cardiovascular disease (CVD) are scarce. Thus, the aim of the current study was to evaluate the influence of dietary factors on serum PON1 in CVD patients. SUBJECTS AND METHODS: Cross-sectional, sub-study of the BALANCE Program Trial. All patients aged 45 years or older and had evidence of established atherosclerotic disease in the preceding 10 years. Body weight, height, waist circumference, blood pressure, lipid profile and fasting glucose were collected. Food intake was assessed with 24-h dietary recall. Data was analyzed using SAS University Edition and a P value ≤ 0.05 was considered statistically significant. Sample was divided into three groups, according to the PON1 T(-107)C genotype (CC, CT and TT) and serum PON1 activity (Low, Medium, High). RESULTS: There were no genotype differences for major factors. However, the systolic blood pressure was lower for CT individuals (p<0.05). Intake of cholesterol, saturated fatty acids (SFA) and monounsaturated fatty acids (MUFAS) was higher in patients with lower PON1 activity. Lipid ingestion tended to be higher in patients with lower PON1 activity (p=0.08). In the multivariate logistic regression model, SFA intake (P=0.03), genotype (P=0.09), gender (P=0.04), age (P=0.07) and carbohydrate intake (P=0.16) contributed the most to the serum PON1 activity. CONCLUSION: Based on these findings, nutritional guidance for these patients becomes essential, since dietary components interact with serum PON1 activity more than genotype.
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spelling pubmed-100653812023-04-01 Factors associated to serum paraoxonase 1 activity in patients with cardiovascular disease Longo, Aline Veiga, Gabriel Barreto Cousen, Maria Isabel Schiavon Karpinski, Caroline Schneider, Augusto Weber, Bernardete Bertoldi, Eduardo Gehling Borges, Lucia Rota Bertacco, Renata Torres Abib Arch Endocrinol Metab Original Article OBJECTIVES: Paraoxonase 1 (PON1) is an enzyme that has antioxidant potential, which confers a protective effect against the atherosclerotic process. However, studies associating genetics, dietary patterns and PON1 activity in individuals with cardiovascular disease (CVD) are scarce. Thus, the aim of the current study was to evaluate the influence of dietary factors on serum PON1 in CVD patients. SUBJECTS AND METHODS: Cross-sectional, sub-study of the BALANCE Program Trial. All patients aged 45 years or older and had evidence of established atherosclerotic disease in the preceding 10 years. Body weight, height, waist circumference, blood pressure, lipid profile and fasting glucose were collected. Food intake was assessed with 24-h dietary recall. Data was analyzed using SAS University Edition and a P value ≤ 0.05 was considered statistically significant. Sample was divided into three groups, according to the PON1 T(-107)C genotype (CC, CT and TT) and serum PON1 activity (Low, Medium, High). RESULTS: There were no genotype differences for major factors. However, the systolic blood pressure was lower for CT individuals (p<0.05). Intake of cholesterol, saturated fatty acids (SFA) and monounsaturated fatty acids (MUFAS) was higher in patients with lower PON1 activity. Lipid ingestion tended to be higher in patients with lower PON1 activity (p=0.08). In the multivariate logistic regression model, SFA intake (P=0.03), genotype (P=0.09), gender (P=0.04), age (P=0.07) and carbohydrate intake (P=0.16) contributed the most to the serum PON1 activity. CONCLUSION: Based on these findings, nutritional guidance for these patients becomes essential, since dietary components interact with serum PON1 activity more than genotype. Sociedade Brasileira de Endocrinologia e Metabologia 2021-04-12 /pmc/articles/PMC10065381/ /pubmed/33844899 http://dx.doi.org/10.20945/2359-3997000000354 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Longo, Aline
Veiga, Gabriel Barreto
Cousen, Maria Isabel Schiavon
Karpinski, Caroline
Schneider, Augusto
Weber, Bernardete
Bertoldi, Eduardo Gehling
Borges, Lucia Rota
Bertacco, Renata Torres Abib
Factors associated to serum paraoxonase 1 activity in patients with cardiovascular disease
title Factors associated to serum paraoxonase 1 activity in patients with cardiovascular disease
title_full Factors associated to serum paraoxonase 1 activity in patients with cardiovascular disease
title_fullStr Factors associated to serum paraoxonase 1 activity in patients with cardiovascular disease
title_full_unstemmed Factors associated to serum paraoxonase 1 activity in patients with cardiovascular disease
title_short Factors associated to serum paraoxonase 1 activity in patients with cardiovascular disease
title_sort factors associated to serum paraoxonase 1 activity in patients with cardiovascular disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065381/
https://www.ncbi.nlm.nih.gov/pubmed/33844899
http://dx.doi.org/10.20945/2359-3997000000354
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