Recent Advances in Nano-Drug Delivery Systems for the Treatment of Diabetic Wound Healing

Diabetes mellitus (DM) induced wound healing impairment remains a serious health problem and burden on the clinical obligation for high amputation rates. Based on the features of wound microenvironment, biomaterials loading specific drugs can benefit diabetic wound treatment. Drug delivery systems (...

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Autores principales: Liu, Mengqian, Wei, Xuerong, Zheng, Zijun, Li, Yicheng, Li, Mengyao, Lin, Jiabao, Yang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065433/
https://www.ncbi.nlm.nih.gov/pubmed/37007988
http://dx.doi.org/10.2147/IJN.S395438
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author Liu, Mengqian
Wei, Xuerong
Zheng, Zijun
Li, Yicheng
Li, Mengyao
Lin, Jiabao
Yang, Lei
author_facet Liu, Mengqian
Wei, Xuerong
Zheng, Zijun
Li, Yicheng
Li, Mengyao
Lin, Jiabao
Yang, Lei
author_sort Liu, Mengqian
collection PubMed
description Diabetes mellitus (DM) induced wound healing impairment remains a serious health problem and burden on the clinical obligation for high amputation rates. Based on the features of wound microenvironment, biomaterials loading specific drugs can benefit diabetic wound treatment. Drug delivery systems (DDSs) can carry diverse functional substances to the wound site. Nano-drug delivery systems (NDDSs), benefiting from their features related to nano size, overcome limitations of conventional DDSs application and are considered as a developing process in the wound treatment field. Recently, a number of finely designed nanocarriers efficiently loading various substances (bioactive and non-bioactive factors) have emerged to circumvent constraints faced by traditional DDSs. This review describes various recent advances of nano-drug delivery systems involved in mitigating diabetes mellitus-based non-healing wounds.
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spelling pubmed-100654332023-04-01 Recent Advances in Nano-Drug Delivery Systems for the Treatment of Diabetic Wound Healing Liu, Mengqian Wei, Xuerong Zheng, Zijun Li, Yicheng Li, Mengyao Lin, Jiabao Yang, Lei Int J Nanomedicine Review Diabetes mellitus (DM) induced wound healing impairment remains a serious health problem and burden on the clinical obligation for high amputation rates. Based on the features of wound microenvironment, biomaterials loading specific drugs can benefit diabetic wound treatment. Drug delivery systems (DDSs) can carry diverse functional substances to the wound site. Nano-drug delivery systems (NDDSs), benefiting from their features related to nano size, overcome limitations of conventional DDSs application and are considered as a developing process in the wound treatment field. Recently, a number of finely designed nanocarriers efficiently loading various substances (bioactive and non-bioactive factors) have emerged to circumvent constraints faced by traditional DDSs. This review describes various recent advances of nano-drug delivery systems involved in mitigating diabetes mellitus-based non-healing wounds. Dove 2023-03-27 /pmc/articles/PMC10065433/ /pubmed/37007988 http://dx.doi.org/10.2147/IJN.S395438 Text en © 2023 Liu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Liu, Mengqian
Wei, Xuerong
Zheng, Zijun
Li, Yicheng
Li, Mengyao
Lin, Jiabao
Yang, Lei
Recent Advances in Nano-Drug Delivery Systems for the Treatment of Diabetic Wound Healing
title Recent Advances in Nano-Drug Delivery Systems for the Treatment of Diabetic Wound Healing
title_full Recent Advances in Nano-Drug Delivery Systems for the Treatment of Diabetic Wound Healing
title_fullStr Recent Advances in Nano-Drug Delivery Systems for the Treatment of Diabetic Wound Healing
title_full_unstemmed Recent Advances in Nano-Drug Delivery Systems for the Treatment of Diabetic Wound Healing
title_short Recent Advances in Nano-Drug Delivery Systems for the Treatment of Diabetic Wound Healing
title_sort recent advances in nano-drug delivery systems for the treatment of diabetic wound healing
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065433/
https://www.ncbi.nlm.nih.gov/pubmed/37007988
http://dx.doi.org/10.2147/IJN.S395438
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