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Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host-microbiome homeostasis

The metalloproteases meprin α and meprin β are highly expressed in the healthy gut but significantly decreased in inflammatory bowel disease, implicating a protective role in mucosal homeostasis. In the colon, meprin α and meprin β form covalently linked heterodimers tethering meprin α to the plasma...

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Detalles Bibliográficos
Autores principales:	Bülck, Cynthia, Nyström, Elisabeth E. L., Koudelka, Tomas, Mannbar-Frahm, Michael, Andresen, Gerrit, Radhouani, Mariem, Tran, Florian, Scharfenberg, Franka, Schrell, Friederike, Armbrust, Fred, Dahlke, Eileen, Zhao, Bei, Vervaeke, Alex, Theilig, Franziska, Rosenstiel, Philip, Starkl, Philipp, Rosshart, Stephan P., Fickenscher, Helmut, Tholey, Andreas, Hansson, Gunnar C., Becker-Pauly, Christoph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065446/ https://www.ncbi.nlm.nih.gov/pubmed/37000885 http://dx.doi.org/10.1126/sciadv.adf4055

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