Cargando…

Predictors for Colorectal Polyps in an Asymptomatic Population Undergoing Medical Check-ups

Colorectal cancer primarily arises from colorectal polyps. Early screening and removal is beneficial, especially in asymptomatic populations. This research aimed to reveal the risk factors detected in medical check-ups for colorectal polyps in asymptomatic people. MATERIALS AND METHODS: Clinical dat...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Chenchen, Wang, Yanan, Zhu, Kongxi, Wang, Xiaoying, Yu, Weihua, Li, Shuai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065822/
https://www.ncbi.nlm.nih.gov/pubmed/36847698
http://dx.doi.org/10.1097/SLE.0000000000001152
_version_ 1785018186604740608
author Zhang, Chenchen
Wang, Yanan
Zhu, Kongxi
Wang, Xiaoying
Yu, Weihua
Li, Shuai
author_facet Zhang, Chenchen
Wang, Yanan
Zhu, Kongxi
Wang, Xiaoying
Yu, Weihua
Li, Shuai
author_sort Zhang, Chenchen
collection PubMed
description Colorectal cancer primarily arises from colorectal polyps. Early screening and removal is beneficial, especially in asymptomatic populations. This research aimed to reveal the risk factors detected in medical check-ups for colorectal polyps in asymptomatic people. MATERIALS AND METHODS: Clinical data of 933 asymptomatic people who underwent colonoscopies from May 2014 to December 2021 was analyzed retrospectively. Data included sex, age, colonoscopy findings, polyp pathology, polyp number, and blood test results. The distribution of colorectal lesions was analyzed. Participants were divided into control and polyp groups, adenomatous and non-adenomatous polyp groups, and single and multiple adenoma groups. RESULTS: Participants’ age, proportion of males, carcinoembryonic antigen (CEA), uric acid and glycosylated hemoglobin levels were significantly higher (P≤0.05) in the polyp group. Age (>40 y), sex (male), and CEA level (>1.435 ng/mL) were independent risk factors for polyps. CEA, uric acid, carbohydrate antigen 19-9, triglyceride, and total cholesterol levels were significantly higher (P<0.05) in the adenoma group than in the non-adenomatous group. CEA level (>1.435 ng/mL) was an independent predictor for adenomas (P<0.05). Participants’ age, proportion of males, CEA, glycosylated hemoglobin, and fasting blood glucose levels were significantly higher (P<0.05) in the multiple adenoma group than in the single group; the high-density lipoprotein cholesterol level was lower (P<0.05). No independent risk factors were found for the number of adenomas. CONCLUSIONS: Serum CEA level (>1.435 ng/mL) was independent risk factor for colorectal polyps. It may be conducive to improve discriminative ability of colorectal cancer risk stratification model.
format Online
Article
Text
id pubmed-10065822
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-100658222023-04-01 Predictors for Colorectal Polyps in an Asymptomatic Population Undergoing Medical Check-ups Zhang, Chenchen Wang, Yanan Zhu, Kongxi Wang, Xiaoying Yu, Weihua Li, Shuai Surg Laparosc Endosc Percutan Tech Original Articles Colorectal cancer primarily arises from colorectal polyps. Early screening and removal is beneficial, especially in asymptomatic populations. This research aimed to reveal the risk factors detected in medical check-ups for colorectal polyps in asymptomatic people. MATERIALS AND METHODS: Clinical data of 933 asymptomatic people who underwent colonoscopies from May 2014 to December 2021 was analyzed retrospectively. Data included sex, age, colonoscopy findings, polyp pathology, polyp number, and blood test results. The distribution of colorectal lesions was analyzed. Participants were divided into control and polyp groups, adenomatous and non-adenomatous polyp groups, and single and multiple adenoma groups. RESULTS: Participants’ age, proportion of males, carcinoembryonic antigen (CEA), uric acid and glycosylated hemoglobin levels were significantly higher (P≤0.05) in the polyp group. Age (>40 y), sex (male), and CEA level (>1.435 ng/mL) were independent risk factors for polyps. CEA, uric acid, carbohydrate antigen 19-9, triglyceride, and total cholesterol levels were significantly higher (P<0.05) in the adenoma group than in the non-adenomatous group. CEA level (>1.435 ng/mL) was an independent predictor for adenomas (P<0.05). Participants’ age, proportion of males, CEA, glycosylated hemoglobin, and fasting blood glucose levels were significantly higher (P<0.05) in the multiple adenoma group than in the single group; the high-density lipoprotein cholesterol level was lower (P<0.05). No independent risk factors were found for the number of adenomas. CONCLUSIONS: Serum CEA level (>1.435 ng/mL) was independent risk factor for colorectal polyps. It may be conducive to improve discriminative ability of colorectal cancer risk stratification model. Lippincott Williams & Wilkins 2023-02-20 /pmc/articles/PMC10065822/ /pubmed/36847698 http://dx.doi.org/10.1097/SLE.0000000000001152 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Original Articles
Zhang, Chenchen
Wang, Yanan
Zhu, Kongxi
Wang, Xiaoying
Yu, Weihua
Li, Shuai
Predictors for Colorectal Polyps in an Asymptomatic Population Undergoing Medical Check-ups
title Predictors for Colorectal Polyps in an Asymptomatic Population Undergoing Medical Check-ups
title_full Predictors for Colorectal Polyps in an Asymptomatic Population Undergoing Medical Check-ups
title_fullStr Predictors for Colorectal Polyps in an Asymptomatic Population Undergoing Medical Check-ups
title_full_unstemmed Predictors for Colorectal Polyps in an Asymptomatic Population Undergoing Medical Check-ups
title_short Predictors for Colorectal Polyps in an Asymptomatic Population Undergoing Medical Check-ups
title_sort predictors for colorectal polyps in an asymptomatic population undergoing medical check-ups
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065822/
https://www.ncbi.nlm.nih.gov/pubmed/36847698
http://dx.doi.org/10.1097/SLE.0000000000001152
work_keys_str_mv AT zhangchenchen predictorsforcolorectalpolypsinanasymptomaticpopulationundergoingmedicalcheckups
AT wangyanan predictorsforcolorectalpolypsinanasymptomaticpopulationundergoingmedicalcheckups
AT zhukongxi predictorsforcolorectalpolypsinanasymptomaticpopulationundergoingmedicalcheckups
AT wangxiaoying predictorsforcolorectalpolypsinanasymptomaticpopulationundergoingmedicalcheckups
AT yuweihua predictorsforcolorectalpolypsinanasymptomaticpopulationundergoingmedicalcheckups
AT lishuai predictorsforcolorectalpolypsinanasymptomaticpopulationundergoingmedicalcheckups