Cargando…

miR-21-5p Inhibits Ferroptosis in Hepatocellular Carcinoma Cells by Regulating the AKT/mTOR Signaling Pathway through MELK

BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most prevalent cancers, and its incidence rate is increasing worldwide. At present, there is no ideal treatment for HCC. In recent years, molecular-targeted therapy has shown significant therapeutic benefits for patients. Ferroptosis is a moda...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Zongqiang, Li, Laibang, Li, Ma, Zhang, Xibing, Zhang, Yu, Ran, Jianghua, Li, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065862/ https://www.ncbi.nlm.nih.gov/pubmed/37008632 http://dx.doi.org/10.1155/2023/8929525

Ejemplares similares

Metformin promotes ferroptosis and sensitivity to sorafenib in hepatocellular carcinoma cells via ATF4/STAT3
por: Hu, Zongqiang, et al.
Publicado: (2023)

MELK promotes Endometrial carcinoma progression via activating mTOR signaling pathway
por: Xu, Qinyang, et al.
Publicado: (2020)

xCT contributes to colorectal cancer tumorigenesis through upregulation of the MELK oncogene and activation of the AKT/mTOR cascade
por: Tang, Bufu, et al.
Publicado: (2022)

Inhibition of the AKT/mTOR pathway negatively regulates PTEN expression via miRNAs: Effect of Akt/mTOR inhibition on PTEN expression
por: Wan, Linyan, et al.
Publicado: (2022)

miR-122 and miR-199 synergistically promote autophagy in oral lichen planus by targeting the Akt/mTOR pathway
por: Wang, Liang, et al.
Publicado: (2019)

Alteration in cardiac PI3K/Akt/mTOR and ERK signaling pathways with the use of growth hormone and swimming, and the roles of miR21 and miR133
por: Palabiyik, Orkide, et al.
Publicado: (2019)

Exosome-derived circCCAR1 promotes CD8 + T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma
por: Hu, Zongqiang, et al.
Publicado: (2023)

Crocin induces autophagic apoptosis in hepatocellular carcinoma by inhibiting Akt/mTOR activity
por: Yao, Chong, et al.
Publicado: (2018)

Dichloroacetate Overcomes Oxaliplatin Chemoresistance in Colorectal Cancer through the miR-543/PTEN/Akt/mTOR Pathway
por: Liang, Yu, et al.
Publicado: (2019)

Upregulated UCA1 contributes to oxaliplatin resistance of hepatocellular carcinoma through inhibition of miR‐138‐5p and activation of AKT/mTOR signaling pathway
por: Huang, Guolin, et al.
Publicado: (2021)

HDAC6, modulated by miR-206, promotes endometrial cancer progression through the PTEN/AKT/mTOR pathway
por: Zheng, Yawen, et al.
Publicado: (2020)

miR-149 Alleviates Ox-LDL-Induced Endothelial Cell Injury by Promoting Autophagy through Akt/mTOR Pathway
por: Zhu, Zhongsheng, et al.
Publicado: (2021)

LncRNA MEG3 inhibits rheumatoid arthritis through miR‐141 and inactivation of AKT/mTOR signalling pathway
por: Li, Guoqing, et al.
Publicado: (2019)

LncRNA NORAD Promotes Proliferation And Inhibits Apoptosis Of Gastric Cancer By Regulating miR-214/Akt/mTOR Axis
por: Tao, Wei, et al.
Publicado: (2019)

miR-451a is underexpressed and targets AKT/mTOR pathway in papillary thyroid carcinoma
por: Minna, Emanuela, et al.
Publicado: (2016)

miR-29c Increases Protein Synthesis in Skeletal Muscle Independently of AKT/mTOR
por: Alves, Paula Ketilly Nascimento, et al.
Publicado: (2022)

Tocopherol attenuates the oxidative stress of BMSCs by inhibiting ferroptosis through the PI3k/AKT/mTOR pathway
por: Lan, Dongmei, et al.
Publicado: (2022)

Hedyotis diffusa Willd. Suppresses Hepatocellular Carcinoma via Downregulating AKT/mTOR Pathways
por: Huang, Lingli, et al.
Publicado: (2021)

PRMT4 promotes hepatocellular carcinoma progression by activating AKT/mTOR signaling and indicates poor prognosis
por: Du, Peng, et al.
Publicado: (2021)

MiR-146b inhibits autophagy in prostate cancer by targeting the PTEN/Akt/mTOR signaling pathway
por: Gao, Song, et al.
Publicado: (2018)

Ursodeoxycholic acid inhibits intimal hyperplasia, vascular smooth muscle cell excessive proliferation, migration via blocking miR-21/PTEN/AKT/mTOR signaling pathway
por: Huang, Rong, et al.
Publicado: (2020)

p53-independent p21 induction by MELK inhibition
por: Matsuda, Tatsuo, et al.
Publicado: (2017)

Ursolic Acid Attenuates Diabetic Mesangial Cell Injury through the Up-Regulation of Autophagy via miRNA-21/PTEN/Akt/mTOR Suppression
por: Lu, Xinxing, et al.
Publicado: (2015)

Arbutin suppresses osteosarcoma progression via miR‐338‐3p/MTHFD1L and inactivation of the AKT/mTOR pathway
por: Wang, Cheng‐Qun, et al.
Publicado: (2020)

MiR-218-5p Suppresses the Progression of Retinoblastoma Through Targeting NACC1 and Inhibiting the AKT/mTOR Signaling Pathway
por: Li, Li, et al.
Publicado: (2020)

NEAT1 knockdown suppresses endothelial cell proliferation and induces apoptosis by regulating miR-638/AKT/mTOR signaling in atherosclerosis
por: Zhang, Xia, et al.
Publicado: (2020)

Homoharringtonine inhibited breast cancer cells growth via miR-18a-3p/AKT/mTOR signaling pathway
por: Wang, Li-bin, et al.
Publicado: (2021)

MiR-193b-5p inhibits proliferation and enhances radio-sensitivity by downregulating the AKT/mTOR signaling pathway in tongue cancer
por: Jiang, Lipeng, et al.
Publicado: (2020)

Correction: miR-451a is underexpressed and targets AKT/mTOR pathway in papillary thyroid carcinoma
por: Minna, Emanuela, et al.
Publicado: (2018)

circACTG1 Promotes Hepatocellular Carcinoma Progression by Regulating miR-940/RIF1 Axis and Activating AKT/mTOR Pathway
por: Wu, Chunchen, et al.
Publicado: (2022)

The Paradox of Akt-mTOR Interactions
por: Vadlakonda, Lakshmipathi, et al.
Publicado: (2013)

Antitumor activity of miR-188-3p in gastric cancer is achieved by targeting CBL expression and inactivating the AKT/mTOR signaling
por: Lin, Jian-Jiao, et al.
Publicado: (2023)

miR-3651 Participates in the Growth Cycle of Hepatocellular Carcinoma Cells and Promotes the Malignant Metastasis via the PI3K/AKT/mTOR Signalling Pathway
por: Liu, Yawei, et al.
Publicado: (2022)

PRMT4 promotes hepatocellular carcinoma progression by activating AKT/mTOR signaling and indicates poor prognosis: Erratum
por: Du, Peng, et al.
Publicado: (2022)

Targeting the PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma
por: Sun, Eun Jin, et al.
Publicado: (2021)

Mediator Complex Subunit 19 Promotes the Development of Hepatocellular Carcinoma by Regulating the AKT/mTOR Signaling Pathway
por: Zhang, Yuting, et al.
Publicado: (2022)

Curcumol inhibits the malignant progression of prostate cancer and regulates the PDK1/AKT/mTOR pathway by targeting miR-9
por: Sheng, Wen, et al.
Publicado: (2021)

miR-29a-3p Regulates Autophagy by Targeting Akt3-Mediated mTOR in SiO(2)-Induced Lung Fibrosis
por: Li, Peiyuan, et al.
Publicado: (2023)

miR-214 ameliorates sepsis-induced acute kidney injury via PTEN/AKT/mTOR-regulated autophagy
por: Sang, Zhenzhen, et al.
Publicado: (2021)

Propofol postpones colorectal cancer development through circ_0026344/miR-645/Akt/mTOR signal pathway
por: Cui, Xiaomin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_1s542mvbv2hmffq5iej0m32h12