MAPK Signaling Pathways in Hepatic Ischemia/Reperfusion Injury

The mitogen-activated protein kinase signaling pathway can be activated by a variety of growth factors, cytokines, and hormones, and mediates numerous intracellular signals related to cellular activities, including cell proliferation, motility, and differentiation. It has been widely studied in the...

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Detalles Bibliográficos
Autores principales: Yu, Bo, Zhang, Yalong, Wang, Tianyu, Guo, Jiayu, Kong, Chenyang, Chen, Zhongbao, Ma, Xiaoxiong, Qiu, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065871/
https://www.ncbi.nlm.nih.gov/pubmed/37012971
http://dx.doi.org/10.2147/JIR.S396604
Descripción
Sumario:The mitogen-activated protein kinase signaling pathway can be activated by a variety of growth factors, cytokines, and hormones, and mediates numerous intracellular signals related to cellular activities, including cell proliferation, motility, and differentiation. It has been widely studied in the occurrence and development of inflammation and tumor. Hepatic ischemia-reperfusion injury (HIRI) is a common pathophysiological phenomenon that occurs in surgical procedures such as lobectomy and liver transplantation, which is characterized by severe inflammatory reaction after ischemia and reperfusion. In this review, we mainly discuss the role of p38, ERK1/2, JNK in MAPK family and TAK1 and ASK1 in MAPKKK family in HIRI, and try to find an effective treatment for HIRI.

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