MAPK Signaling Pathways in Hepatic Ischemia/Reperfusion Injury

The mitogen-activated protein kinase signaling pathway can be activated by a variety of growth factors, cytokines, and hormones, and mediates numerous intracellular signals related to cellular activities, including cell proliferation, motility, and differentiation. It has been widely studied in the...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Bo, Zhang, Yalong, Wang, Tianyu, Guo, Jiayu, Kong, Chenyang, Chen, Zhongbao, Ma, Xiaoxiong, Qiu, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065871/
https://www.ncbi.nlm.nih.gov/pubmed/37012971
http://dx.doi.org/10.2147/JIR.S396604
_version_ 1785018197302312960
author Yu, Bo
Zhang, Yalong
Wang, Tianyu
Guo, Jiayu
Kong, Chenyang
Chen, Zhongbao
Ma, Xiaoxiong
Qiu, Tao
author_facet Yu, Bo
Zhang, Yalong
Wang, Tianyu
Guo, Jiayu
Kong, Chenyang
Chen, Zhongbao
Ma, Xiaoxiong
Qiu, Tao
author_sort Yu, Bo
collection PubMed
description The mitogen-activated protein kinase signaling pathway can be activated by a variety of growth factors, cytokines, and hormones, and mediates numerous intracellular signals related to cellular activities, including cell proliferation, motility, and differentiation. It has been widely studied in the occurrence and development of inflammation and tumor. Hepatic ischemia-reperfusion injury (HIRI) is a common pathophysiological phenomenon that occurs in surgical procedures such as lobectomy and liver transplantation, which is characterized by severe inflammatory reaction after ischemia and reperfusion. In this review, we mainly discuss the role of p38, ERK1/2, JNK in MAPK family and TAK1 and ASK1 in MAPKKK family in HIRI, and try to find an effective treatment for HIRI.
format Online
Article
Text
id pubmed-10065871
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-100658712023-04-02 MAPK Signaling Pathways in Hepatic Ischemia/Reperfusion Injury Yu, Bo Zhang, Yalong Wang, Tianyu Guo, Jiayu Kong, Chenyang Chen, Zhongbao Ma, Xiaoxiong Qiu, Tao J Inflamm Res Review The mitogen-activated protein kinase signaling pathway can be activated by a variety of growth factors, cytokines, and hormones, and mediates numerous intracellular signals related to cellular activities, including cell proliferation, motility, and differentiation. It has been widely studied in the occurrence and development of inflammation and tumor. Hepatic ischemia-reperfusion injury (HIRI) is a common pathophysiological phenomenon that occurs in surgical procedures such as lobectomy and liver transplantation, which is characterized by severe inflammatory reaction after ischemia and reperfusion. In this review, we mainly discuss the role of p38, ERK1/2, JNK in MAPK family and TAK1 and ASK1 in MAPKKK family in HIRI, and try to find an effective treatment for HIRI. Dove 2023-03-27 /pmc/articles/PMC10065871/ /pubmed/37012971 http://dx.doi.org/10.2147/JIR.S396604 Text en © 2023 Yu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Yu, Bo
Zhang, Yalong
Wang, Tianyu
Guo, Jiayu
Kong, Chenyang
Chen, Zhongbao
Ma, Xiaoxiong
Qiu, Tao
MAPK Signaling Pathways in Hepatic Ischemia/Reperfusion Injury
title MAPK Signaling Pathways in Hepatic Ischemia/Reperfusion Injury
title_full MAPK Signaling Pathways in Hepatic Ischemia/Reperfusion Injury
title_fullStr MAPK Signaling Pathways in Hepatic Ischemia/Reperfusion Injury
title_full_unstemmed MAPK Signaling Pathways in Hepatic Ischemia/Reperfusion Injury
title_short MAPK Signaling Pathways in Hepatic Ischemia/Reperfusion Injury
title_sort mapk signaling pathways in hepatic ischemia/reperfusion injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10065871/
https://www.ncbi.nlm.nih.gov/pubmed/37012971
http://dx.doi.org/10.2147/JIR.S396604
work_keys_str_mv AT yubo mapksignalingpathwaysinhepaticischemiareperfusioninjury
AT zhangyalong mapksignalingpathwaysinhepaticischemiareperfusioninjury
AT wangtianyu mapksignalingpathwaysinhepaticischemiareperfusioninjury
AT guojiayu mapksignalingpathwaysinhepaticischemiareperfusioninjury
AT kongchenyang mapksignalingpathwaysinhepaticischemiareperfusioninjury
AT chenzhongbao mapksignalingpathwaysinhepaticischemiareperfusioninjury
AT maxiaoxiong mapksignalingpathwaysinhepaticischemiareperfusioninjury
AT qiutao mapksignalingpathwaysinhepaticischemiareperfusioninjury

Ejemplares similares