Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut

Bile acids (BAs) mediate the crosstalk between human and microbial cells and influence diseases including Clostridioides difficile infection (CDI). While bile salt hydrolases (BSHs) shape the BA pool by deconjugating conjugated BAs, the basis for their substrate selectivity and impact on C. difficil...

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Detalles Bibliográficos
Autores principales: Foley, Matthew H., Walker, Morgan E., Stewart, Allison K., O’Flaherty, Sarah, Gentry, Emily C., Patel, Shakshi, Beaty, Violet V., Allen, Garrison, Pan, Meichen, Simpson, Joshua B., Perkins, Caroline, Vanhoy, Molly E., Dougherty, Michael K., McGill, Sarah K., Gulati, Ajay S., Dorrestein, Pieter C., Baker, Erin S., Redinbo, Matthew R., Barrangou, Rodolphe, Theriot, Casey M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066039/
https://www.ncbi.nlm.nih.gov/pubmed/36914755
http://dx.doi.org/10.1038/s41564-023-01337-7

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