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The incidence of non-affective psychotic disorders in low and middle-income countries: a systematic review and meta-analysis

PURPOSE: Global understanding of the epidemiological landscape of non-affective psychotic disorders (NAPD) is predominantly based on studies from high-income countries. We sought to systematically review and meta-analyse all incidence studies conducted in low and middle-income countries (LMICs). MET...

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Autores principales: Bastien, Rayanne John-Baptiste, Ding, Tao, Gonzalez-Valderrama, Alfonso, Valmaggia, Lucia, Kirkbride, James B., Jongsma, Hannah E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066134/
https://www.ncbi.nlm.nih.gov/pubmed/36547685
http://dx.doi.org/10.1007/s00127-022-02397-6
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author Bastien, Rayanne John-Baptiste
Ding, Tao
Gonzalez-Valderrama, Alfonso
Valmaggia, Lucia
Kirkbride, James B.
Jongsma, Hannah E.
author_facet Bastien, Rayanne John-Baptiste
Ding, Tao
Gonzalez-Valderrama, Alfonso
Valmaggia, Lucia
Kirkbride, James B.
Jongsma, Hannah E.
author_sort Bastien, Rayanne John-Baptiste
collection PubMed
description PURPOSE: Global understanding of the epidemiological landscape of non-affective psychotic disorders (NAPD) is predominantly based on studies from high-income countries. We sought to systematically review and meta-analyse all incidence studies conducted in low and middle-income countries (LMICs). METHODS: We systematically searched four databases using terms for NAPD, incidence and LMICs. Citations were eligible for inclusion if: published between 1 January 1960 and 31 May 2022; wholly or partially conducted in an LMIC, and; containing data on NAPD incidence in the general adult population. Two independent raters assessed study quality according to previously published criteria. We conducted a narrative synthesis and random-effects meta-analyses where sufficient studies were available (N ≥ 5). RESULTS: We retrieved 11 421 records, of which 23 citations met inclusion criteria from 18 unique studies across 19 settings in 10 LMICs. Median study quality was 4 out of 7 (interquartile range: 3–6). The crude incidence of NAPD varied around 4.2 times, from 10.0 per 100,000 person-years (95% confidence interval [CI] 8.7–11.4) in Brazil to 42.0 (95%CI 32.2–54.8) in India, with marked heterogeneity in methodologies and rates. Our 60-year review highlights the dearth of robust evidence on the incidence of psychotic disorders in LMICs. CONCLUSION: Without reliable, contemporary estimates of this fundamental cornerstone of population health, it is impossible to understand the true burden, distribution or causes of psychotic disorders in over 87% of the world’s population. A new, more equitable global mental health evidence base for NAPD is now urgently required. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00127-022-02397-6.
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spelling pubmed-100661342023-04-02 The incidence of non-affective psychotic disorders in low and middle-income countries: a systematic review and meta-analysis Bastien, Rayanne John-Baptiste Ding, Tao Gonzalez-Valderrama, Alfonso Valmaggia, Lucia Kirkbride, James B. Jongsma, Hannah E. Soc Psychiatry Psychiatr Epidemiol Original Paper PURPOSE: Global understanding of the epidemiological landscape of non-affective psychotic disorders (NAPD) is predominantly based on studies from high-income countries. We sought to systematically review and meta-analyse all incidence studies conducted in low and middle-income countries (LMICs). METHODS: We systematically searched four databases using terms for NAPD, incidence and LMICs. Citations were eligible for inclusion if: published between 1 January 1960 and 31 May 2022; wholly or partially conducted in an LMIC, and; containing data on NAPD incidence in the general adult population. Two independent raters assessed study quality according to previously published criteria. We conducted a narrative synthesis and random-effects meta-analyses where sufficient studies were available (N ≥ 5). RESULTS: We retrieved 11 421 records, of which 23 citations met inclusion criteria from 18 unique studies across 19 settings in 10 LMICs. Median study quality was 4 out of 7 (interquartile range: 3–6). The crude incidence of NAPD varied around 4.2 times, from 10.0 per 100,000 person-years (95% confidence interval [CI] 8.7–11.4) in Brazil to 42.0 (95%CI 32.2–54.8) in India, with marked heterogeneity in methodologies and rates. Our 60-year review highlights the dearth of robust evidence on the incidence of psychotic disorders in LMICs. CONCLUSION: Without reliable, contemporary estimates of this fundamental cornerstone of population health, it is impossible to understand the true burden, distribution or causes of psychotic disorders in over 87% of the world’s population. A new, more equitable global mental health evidence base for NAPD is now urgently required. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00127-022-02397-6. Springer Berlin Heidelberg 2022-12-22 2023 /pmc/articles/PMC10066134/ /pubmed/36547685 http://dx.doi.org/10.1007/s00127-022-02397-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Paper
Bastien, Rayanne John-Baptiste
Ding, Tao
Gonzalez-Valderrama, Alfonso
Valmaggia, Lucia
Kirkbride, James B.
Jongsma, Hannah E.
The incidence of non-affective psychotic disorders in low and middle-income countries: a systematic review and meta-analysis
title The incidence of non-affective psychotic disorders in low and middle-income countries: a systematic review and meta-analysis
title_full The incidence of non-affective psychotic disorders in low and middle-income countries: a systematic review and meta-analysis
title_fullStr The incidence of non-affective psychotic disorders in low and middle-income countries: a systematic review and meta-analysis
title_full_unstemmed The incidence of non-affective psychotic disorders in low and middle-income countries: a systematic review and meta-analysis
title_short The incidence of non-affective psychotic disorders in low and middle-income countries: a systematic review and meta-analysis
title_sort incidence of non-affective psychotic disorders in low and middle-income countries: a systematic review and meta-analysis
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066134/
https://www.ncbi.nlm.nih.gov/pubmed/36547685
http://dx.doi.org/10.1007/s00127-022-02397-6
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