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Application of (123)I-MIBG myocardial maximum standardized uptake value to characterize cardiac function in patients with pheochromocytoma: comparison with echocardiography
PURPOSE: This study examined the usefulness of the maximum standardized uptake value (SUVmax) of myocardial [(123)I]-metaiodobenzylguanidine ([(123)I]-MIBG) to characterize myocardial function by comparing it with echocardiographic parameters in patients with pheochromocytoma. MATERIALS AND METHODS:...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Nature Singapore
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066163/ https://www.ncbi.nlm.nih.gov/pubmed/36441441 http://dx.doi.org/10.1007/s11604-022-01365-z |
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author | Nakajo, Masatoyo Horizoe, Yoshihisa Kawaji, Kodai Jinguji, Megumi Tani, Atsushi Fukukura, Yoshihiko Ohishi, Mitsuru Yoshiura, Takashi |
author_facet | Nakajo, Masatoyo Horizoe, Yoshihisa Kawaji, Kodai Jinguji, Megumi Tani, Atsushi Fukukura, Yoshihiko Ohishi, Mitsuru Yoshiura, Takashi |
author_sort | Nakajo, Masatoyo |
collection | PubMed |
description | PURPOSE: This study examined the usefulness of the maximum standardized uptake value (SUVmax) of myocardial [(123)I]-metaiodobenzylguanidine ([(123)I]-MIBG) to characterize myocardial function by comparing it with echocardiographic parameters in patients with pheochromocytoma. MATERIALS AND METHODS: This study included 18 patients with pheochromocytoma who underwent both planar and [(123)I]-MIBG single-photon emission computed tomography/computed tomography scans and echocardiography before surgery. Myocardial [(123)I]-MIBG visibility and SUVmax were compared with echocardiographic parameters related to systolic and diastolic functions. The Mann–Whitney U test, Fisher exact test, or Spearman rank correlation assessed differences or relationships between two quantitative variables. RESULTS: On visual analysis, 6 patients showed normal myocardial [(123)I]-MIBG uptake, whereas 12 patients showed decreased myocardial [(123)I]-MIBG uptake. No patients showed systolic dysfunction. A significant difference was observed in the incidence of diastolic dysfunction between the groups with normal and decreased uptake (p = 0.009), and left ventricular (LV) diastolic dysfunction was observed in 9 (75%) of 12 patients with decreased myocardial uptake. The myocardial SUVmax was significantly lower in 9 patients with LV diastolic dysfunction than in 9 patients with normal cardiac function (1.67 ± 0.37 vs. 3.03 ± 1.38, p = 0.047). Myocardial SUVmax was positively correlated with septal e′ (early diastolic velocity of septal mitral annulus) (ρ = 0.51, p = 0.031) and negatively correlated with the septal E/e′ ratio (early mitral E-velocity to early diastolic velocity of septal mitral annulus; ρ = − 0.64, p = 0.004), respectively. CONCLUSIONS: LV diastolic dysfunction was inversely related to myocardial [(123)I]-MIBG uptake. Myocardial [(123)I]-MIBG SUVmax may be useful for characterizing cardiac function in patients with pheochromocytoma. Second abstract. The semiquantitative analysis using the myocardial SUVmax in (123)I-MIBG SPECT/CT was found to be potentially useful for characterizing cardiac function in patients with pheochromocytoma. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11604-022-01365-z. |
format | Online Article Text |
id | pubmed-10066163 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Nature Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-100661632023-04-02 Application of (123)I-MIBG myocardial maximum standardized uptake value to characterize cardiac function in patients with pheochromocytoma: comparison with echocardiography Nakajo, Masatoyo Horizoe, Yoshihisa Kawaji, Kodai Jinguji, Megumi Tani, Atsushi Fukukura, Yoshihiko Ohishi, Mitsuru Yoshiura, Takashi Jpn J Radiol Original Article PURPOSE: This study examined the usefulness of the maximum standardized uptake value (SUVmax) of myocardial [(123)I]-metaiodobenzylguanidine ([(123)I]-MIBG) to characterize myocardial function by comparing it with echocardiographic parameters in patients with pheochromocytoma. MATERIALS AND METHODS: This study included 18 patients with pheochromocytoma who underwent both planar and [(123)I]-MIBG single-photon emission computed tomography/computed tomography scans and echocardiography before surgery. Myocardial [(123)I]-MIBG visibility and SUVmax were compared with echocardiographic parameters related to systolic and diastolic functions. The Mann–Whitney U test, Fisher exact test, or Spearman rank correlation assessed differences or relationships between two quantitative variables. RESULTS: On visual analysis, 6 patients showed normal myocardial [(123)I]-MIBG uptake, whereas 12 patients showed decreased myocardial [(123)I]-MIBG uptake. No patients showed systolic dysfunction. A significant difference was observed in the incidence of diastolic dysfunction between the groups with normal and decreased uptake (p = 0.009), and left ventricular (LV) diastolic dysfunction was observed in 9 (75%) of 12 patients with decreased myocardial uptake. The myocardial SUVmax was significantly lower in 9 patients with LV diastolic dysfunction than in 9 patients with normal cardiac function (1.67 ± 0.37 vs. 3.03 ± 1.38, p = 0.047). Myocardial SUVmax was positively correlated with septal e′ (early diastolic velocity of septal mitral annulus) (ρ = 0.51, p = 0.031) and negatively correlated with the septal E/e′ ratio (early mitral E-velocity to early diastolic velocity of septal mitral annulus; ρ = − 0.64, p = 0.004), respectively. CONCLUSIONS: LV diastolic dysfunction was inversely related to myocardial [(123)I]-MIBG uptake. Myocardial [(123)I]-MIBG SUVmax may be useful for characterizing cardiac function in patients with pheochromocytoma. Second abstract. The semiquantitative analysis using the myocardial SUVmax in (123)I-MIBG SPECT/CT was found to be potentially useful for characterizing cardiac function in patients with pheochromocytoma. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11604-022-01365-z. Springer Nature Singapore 2022-11-28 2023 /pmc/articles/PMC10066163/ /pubmed/36441441 http://dx.doi.org/10.1007/s11604-022-01365-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Nakajo, Masatoyo Horizoe, Yoshihisa Kawaji, Kodai Jinguji, Megumi Tani, Atsushi Fukukura, Yoshihiko Ohishi, Mitsuru Yoshiura, Takashi Application of (123)I-MIBG myocardial maximum standardized uptake value to characterize cardiac function in patients with pheochromocytoma: comparison with echocardiography |
title | Application of (123)I-MIBG myocardial maximum standardized uptake value to characterize cardiac function in patients with pheochromocytoma: comparison with echocardiography |
title_full | Application of (123)I-MIBG myocardial maximum standardized uptake value to characterize cardiac function in patients with pheochromocytoma: comparison with echocardiography |
title_fullStr | Application of (123)I-MIBG myocardial maximum standardized uptake value to characterize cardiac function in patients with pheochromocytoma: comparison with echocardiography |
title_full_unstemmed | Application of (123)I-MIBG myocardial maximum standardized uptake value to characterize cardiac function in patients with pheochromocytoma: comparison with echocardiography |
title_short | Application of (123)I-MIBG myocardial maximum standardized uptake value to characterize cardiac function in patients with pheochromocytoma: comparison with echocardiography |
title_sort | application of (123)i-mibg myocardial maximum standardized uptake value to characterize cardiac function in patients with pheochromocytoma: comparison with echocardiography |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066163/ https://www.ncbi.nlm.nih.gov/pubmed/36441441 http://dx.doi.org/10.1007/s11604-022-01365-z |
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