Inhibition of TRADD ameliorates chondrocyte necroptosis and osteoarthritis by blocking RIPK1-TAK1 pathway and restoring autophagy

Osteoarthritis (OA) is an age-related disease characterized by cartilage degeneration. TNFR1-associated death domain protein (TRADD) is a key upstream molecule of TNF-α signals but its role in OA pathogenesis is unknown. This study aimed to verify that whether inhibition of TRADD could protect again...

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Detalles Bibliográficos
Autores principales: Sun, Kai, Guo, Zhou, Zhang, Jinming, Hou, Liangcai, Liang, Shuang, Lu, Fan, Wang, Genchun, Xu, Jingting, Zhang, Xiong, Guo, Fengjing, Zhu, Wentao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066284/
https://www.ncbi.nlm.nih.gov/pubmed/37002200
http://dx.doi.org/10.1038/s41420-023-01406-0

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