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Structural insights into the mechanism of leptin receptor activation

Leptin is an adipocyte-derived protein hormone that promotes satiety and energy homeostasis by activating the leptin receptor (LepR)–STAT3 signaling axis in a subset of hypothalamic neurons. Leptin signaling is dysregulated in obesity, however, where appetite remains elevated despite high levels of...

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Detalles Bibliográficos
Autores principales:	Saxton, Robert A., Caveney, Nathanael A., Moya-Garzon, Maria Dolores, Householder, Karsten D., Rodriguez, Grayson E., Burdsall, Kylie A., Long, Jonathan Z., Garcia, K. Christopher
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066393/ https://www.ncbi.nlm.nih.gov/pubmed/37002197 http://dx.doi.org/10.1038/s41467-023-37169-6

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