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Veneto Region dementia-related mortality during the COVID-19 pandemic: multiple causes of death and time series analysis

BACKGROUND: Older individuals with dementia have been severely affected by the COVID-19 pandemic. There is a lack of in-depth evaluation of mortality trends using both the underlying cause of death (UCOD) and the multiple causes of death (MCOD) approaches. The objective of this study was to determin...

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Autores principales: Basso, Cristina, Barbiellini Amidei, Claudio, Casotto, Veronica, Schievano, Elena, Dotto, Matilde, Tiozzo Netti, Silvia, Zorzi, Manuel, Fedeli, Ugo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066484/
https://www.ncbi.nlm.nih.gov/pubmed/36847686
http://dx.doi.org/10.1093/eurpub/ckad005
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author Basso, Cristina
Barbiellini Amidei, Claudio
Casotto, Veronica
Schievano, Elena
Dotto, Matilde
Tiozzo Netti, Silvia
Zorzi, Manuel
Fedeli, Ugo
author_facet Basso, Cristina
Barbiellini Amidei, Claudio
Casotto, Veronica
Schievano, Elena
Dotto, Matilde
Tiozzo Netti, Silvia
Zorzi, Manuel
Fedeli, Ugo
author_sort Basso, Cristina
collection PubMed
description BACKGROUND: Older individuals with dementia have been severely affected by the COVID-19 pandemic. There is a lack of in-depth evaluation of mortality trends using both the underlying cause of death (UCOD) and the multiple causes of death (MCOD) approaches. The objective of this study was to determine the impact of the COVID-19 pandemic on dementia-related deaths considering comorbidities and the place of death. METHODS: This retrospective, population-based study was conducted in Veneto, Italy. All the death certificates of individuals aged ≥65 years issued from 2008 to 2020 were analyzed for dementia-related mortality using age-standardized sex-stratified rates of dementia as UCOD and MCOD. Excess in monthly dementia-related mortality in 2020 was estimated by applying Seasonal Autoregressive Integrated Moving Average (SARIMA) model. RESULTS: Overall, 70 301 death certificates reported dementia (MCOD proportional mortality: 12.9%), and 37 604 cases identified it as UCOD (proportional mortality: 6.9%). In 2020, the MCOD proportional mortality increased to 14.3% whereas that of UCOD remained static (7.0%). Compared to the SARIMA prediction, MCOD increased by 15.5% in males and 18.3% in females in 2020. Compared to the 2018–19 average, deaths in nursing homes increased by 32% in 2020, at home by 26% and in hospitals by 12%. CONCLUSIONS: An increase in dementia-related mortality during the first months of the COVID-19 pandemic could only be detected using the MCOD approach. MCOD proved to be more robust, and hence, should be included in future analyses. Nursing homes appeared to be the most critical setting which should guide establishing protective measures for similar situations.
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spelling pubmed-100664842023-04-02 Veneto Region dementia-related mortality during the COVID-19 pandemic: multiple causes of death and time series analysis Basso, Cristina Barbiellini Amidei, Claudio Casotto, Veronica Schievano, Elena Dotto, Matilde Tiozzo Netti, Silvia Zorzi, Manuel Fedeli, Ugo Eur J Public Health Covid-19 BACKGROUND: Older individuals with dementia have been severely affected by the COVID-19 pandemic. There is a lack of in-depth evaluation of mortality trends using both the underlying cause of death (UCOD) and the multiple causes of death (MCOD) approaches. The objective of this study was to determine the impact of the COVID-19 pandemic on dementia-related deaths considering comorbidities and the place of death. METHODS: This retrospective, population-based study was conducted in Veneto, Italy. All the death certificates of individuals aged ≥65 years issued from 2008 to 2020 were analyzed for dementia-related mortality using age-standardized sex-stratified rates of dementia as UCOD and MCOD. Excess in monthly dementia-related mortality in 2020 was estimated by applying Seasonal Autoregressive Integrated Moving Average (SARIMA) model. RESULTS: Overall, 70 301 death certificates reported dementia (MCOD proportional mortality: 12.9%), and 37 604 cases identified it as UCOD (proportional mortality: 6.9%). In 2020, the MCOD proportional mortality increased to 14.3% whereas that of UCOD remained static (7.0%). Compared to the SARIMA prediction, MCOD increased by 15.5% in males and 18.3% in females in 2020. Compared to the 2018–19 average, deaths in nursing homes increased by 32% in 2020, at home by 26% and in hospitals by 12%. CONCLUSIONS: An increase in dementia-related mortality during the first months of the COVID-19 pandemic could only be detected using the MCOD approach. MCOD proved to be more robust, and hence, should be included in future analyses. Nursing homes appeared to be the most critical setting which should guide establishing protective measures for similar situations. Oxford University Press 2023-02-27 /pmc/articles/PMC10066484/ /pubmed/36847686 http://dx.doi.org/10.1093/eurpub/ckad005 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the European Public Health Association. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Covid-19
Basso, Cristina
Barbiellini Amidei, Claudio
Casotto, Veronica
Schievano, Elena
Dotto, Matilde
Tiozzo Netti, Silvia
Zorzi, Manuel
Fedeli, Ugo
Veneto Region dementia-related mortality during the COVID-19 pandemic: multiple causes of death and time series analysis
title Veneto Region dementia-related mortality during the COVID-19 pandemic: multiple causes of death and time series analysis
title_full Veneto Region dementia-related mortality during the COVID-19 pandemic: multiple causes of death and time series analysis
title_fullStr Veneto Region dementia-related mortality during the COVID-19 pandemic: multiple causes of death and time series analysis
title_full_unstemmed Veneto Region dementia-related mortality during the COVID-19 pandemic: multiple causes of death and time series analysis
title_short Veneto Region dementia-related mortality during the COVID-19 pandemic: multiple causes of death and time series analysis
title_sort veneto region dementia-related mortality during the covid-19 pandemic: multiple causes of death and time series analysis
topic Covid-19
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066484/
https://www.ncbi.nlm.nih.gov/pubmed/36847686
http://dx.doi.org/10.1093/eurpub/ckad005
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