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Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep

Thalamoreticular circuitry plays a key role in arousal, attention, cognition, and sleep spindles, and is linked to several brain disorders. A detailed computational model of mouse somatosensory thalamus and thalamic reticular nucleus has been developed to capture the properties of over 14,000 neuron...

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Autores principales: Iavarone, Elisabetta, Simko, Jane, Shi, Ying, Bertschy, Marine, García-Amado, María, Litvak, Polina, Kaufmann, Anna-Kristin, O’Reilly, Christian, Amsalem, Oren, Abdellah, Marwan, Chevtchenko, Grigori, Coste, Benoît, Courcol, Jean-Denis, Ecker, András, Favreau, Cyrille, Fleury, Adrien Christian, Van Geit, Werner, Gevaert, Michael, Guerrero, Nadir Román, Herttuainen, Joni, Ivaska, Genrich, Kerrien, Samuel, King, James G., Kumbhar, Pramod, Lurie, Patrycja, Magkanaris, Ioannis, Muddapu, Vignayanandam Ravindernath, Nair, Jayakrishnan, Pereira, Fernando L., Perin, Rodrigo, Petitjean, Fabien, Ranjan, Rajnish, Reimann, Michael, Soltuzu, Liviu, Sy, Mohameth François, Tuncel, M. Anıl, Ulbrich, Alexander, Wolf, Matthias, Clascá, Francisco, Markram, Henry, Hill, Sean L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066598/
https://www.ncbi.nlm.nih.gov/pubmed/36867532
http://dx.doi.org/10.1016/j.celrep.2023.112200
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author Iavarone, Elisabetta
Simko, Jane
Shi, Ying
Bertschy, Marine
García-Amado, María
Litvak, Polina
Kaufmann, Anna-Kristin
O’Reilly, Christian
Amsalem, Oren
Abdellah, Marwan
Chevtchenko, Grigori
Coste, Benoît
Courcol, Jean-Denis
Ecker, András
Favreau, Cyrille
Fleury, Adrien Christian
Van Geit, Werner
Gevaert, Michael
Guerrero, Nadir Román
Herttuainen, Joni
Ivaska, Genrich
Kerrien, Samuel
King, James G.
Kumbhar, Pramod
Lurie, Patrycja
Magkanaris, Ioannis
Muddapu, Vignayanandam Ravindernath
Nair, Jayakrishnan
Pereira, Fernando L.
Perin, Rodrigo
Petitjean, Fabien
Ranjan, Rajnish
Reimann, Michael
Soltuzu, Liviu
Sy, Mohameth François
Tuncel, M. Anıl
Ulbrich, Alexander
Wolf, Matthias
Clascá, Francisco
Markram, Henry
Hill, Sean L.
author_facet Iavarone, Elisabetta
Simko, Jane
Shi, Ying
Bertschy, Marine
García-Amado, María
Litvak, Polina
Kaufmann, Anna-Kristin
O’Reilly, Christian
Amsalem, Oren
Abdellah, Marwan
Chevtchenko, Grigori
Coste, Benoît
Courcol, Jean-Denis
Ecker, András
Favreau, Cyrille
Fleury, Adrien Christian
Van Geit, Werner
Gevaert, Michael
Guerrero, Nadir Román
Herttuainen, Joni
Ivaska, Genrich
Kerrien, Samuel
King, James G.
Kumbhar, Pramod
Lurie, Patrycja
Magkanaris, Ioannis
Muddapu, Vignayanandam Ravindernath
Nair, Jayakrishnan
Pereira, Fernando L.
Perin, Rodrigo
Petitjean, Fabien
Ranjan, Rajnish
Reimann, Michael
Soltuzu, Liviu
Sy, Mohameth François
Tuncel, M. Anıl
Ulbrich, Alexander
Wolf, Matthias
Clascá, Francisco
Markram, Henry
Hill, Sean L.
author_sort Iavarone, Elisabetta
collection PubMed
description Thalamoreticular circuitry plays a key role in arousal, attention, cognition, and sleep spindles, and is linked to several brain disorders. A detailed computational model of mouse somatosensory thalamus and thalamic reticular nucleus has been developed to capture the properties of over 14,000 neurons connected by 6 million synapses. The model recreates the biological connectivity of these neurons, and simulations of the model reproduce multiple experimental findings in different brain states. The model shows that inhibitory rebound produces frequency-selective enhancement of thalamic responses during wakefulness. We find that thalamic interactions are responsible for the characteristic waxing and waning of spindle oscillations. In addition, we find that changes in thalamic excitability control spindle frequency and their incidence. The model is made openly available to provide a new tool for studying the function and dysfunction of the thalamoreticular circuitry in various brain states.
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spelling pubmed-100665982023-04-02 Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep Iavarone, Elisabetta Simko, Jane Shi, Ying Bertschy, Marine García-Amado, María Litvak, Polina Kaufmann, Anna-Kristin O’Reilly, Christian Amsalem, Oren Abdellah, Marwan Chevtchenko, Grigori Coste, Benoît Courcol, Jean-Denis Ecker, András Favreau, Cyrille Fleury, Adrien Christian Van Geit, Werner Gevaert, Michael Guerrero, Nadir Román Herttuainen, Joni Ivaska, Genrich Kerrien, Samuel King, James G. Kumbhar, Pramod Lurie, Patrycja Magkanaris, Ioannis Muddapu, Vignayanandam Ravindernath Nair, Jayakrishnan Pereira, Fernando L. Perin, Rodrigo Petitjean, Fabien Ranjan, Rajnish Reimann, Michael Soltuzu, Liviu Sy, Mohameth François Tuncel, M. Anıl Ulbrich, Alexander Wolf, Matthias Clascá, Francisco Markram, Henry Hill, Sean L. Cell Rep Resource Thalamoreticular circuitry plays a key role in arousal, attention, cognition, and sleep spindles, and is linked to several brain disorders. A detailed computational model of mouse somatosensory thalamus and thalamic reticular nucleus has been developed to capture the properties of over 14,000 neurons connected by 6 million synapses. The model recreates the biological connectivity of these neurons, and simulations of the model reproduce multiple experimental findings in different brain states. The model shows that inhibitory rebound produces frequency-selective enhancement of thalamic responses during wakefulness. We find that thalamic interactions are responsible for the characteristic waxing and waning of spindle oscillations. In addition, we find that changes in thalamic excitability control spindle frequency and their incidence. The model is made openly available to provide a new tool for studying the function and dysfunction of the thalamoreticular circuitry in various brain states. Cell Press 2023-03-01 /pmc/articles/PMC10066598/ /pubmed/36867532 http://dx.doi.org/10.1016/j.celrep.2023.112200 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Resource
Iavarone, Elisabetta
Simko, Jane
Shi, Ying
Bertschy, Marine
García-Amado, María
Litvak, Polina
Kaufmann, Anna-Kristin
O’Reilly, Christian
Amsalem, Oren
Abdellah, Marwan
Chevtchenko, Grigori
Coste, Benoît
Courcol, Jean-Denis
Ecker, András
Favreau, Cyrille
Fleury, Adrien Christian
Van Geit, Werner
Gevaert, Michael
Guerrero, Nadir Román
Herttuainen, Joni
Ivaska, Genrich
Kerrien, Samuel
King, James G.
Kumbhar, Pramod
Lurie, Patrycja
Magkanaris, Ioannis
Muddapu, Vignayanandam Ravindernath
Nair, Jayakrishnan
Pereira, Fernando L.
Perin, Rodrigo
Petitjean, Fabien
Ranjan, Rajnish
Reimann, Michael
Soltuzu, Liviu
Sy, Mohameth François
Tuncel, M. Anıl
Ulbrich, Alexander
Wolf, Matthias
Clascá, Francisco
Markram, Henry
Hill, Sean L.
Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep
title Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep
title_full Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep
title_fullStr Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep
title_full_unstemmed Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep
title_short Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep
title_sort thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep
topic Resource
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066598/
https://www.ncbi.nlm.nih.gov/pubmed/36867532
http://dx.doi.org/10.1016/j.celrep.2023.112200
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