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Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep
Thalamoreticular circuitry plays a key role in arousal, attention, cognition, and sleep spindles, and is linked to several brain disorders. A detailed computational model of mouse somatosensory thalamus and thalamic reticular nucleus has been developed to capture the properties of over 14,000 neuron...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066598/ https://www.ncbi.nlm.nih.gov/pubmed/36867532 http://dx.doi.org/10.1016/j.celrep.2023.112200 |
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author | Iavarone, Elisabetta Simko, Jane Shi, Ying Bertschy, Marine García-Amado, María Litvak, Polina Kaufmann, Anna-Kristin O’Reilly, Christian Amsalem, Oren Abdellah, Marwan Chevtchenko, Grigori Coste, Benoît Courcol, Jean-Denis Ecker, András Favreau, Cyrille Fleury, Adrien Christian Van Geit, Werner Gevaert, Michael Guerrero, Nadir Román Herttuainen, Joni Ivaska, Genrich Kerrien, Samuel King, James G. Kumbhar, Pramod Lurie, Patrycja Magkanaris, Ioannis Muddapu, Vignayanandam Ravindernath Nair, Jayakrishnan Pereira, Fernando L. Perin, Rodrigo Petitjean, Fabien Ranjan, Rajnish Reimann, Michael Soltuzu, Liviu Sy, Mohameth François Tuncel, M. Anıl Ulbrich, Alexander Wolf, Matthias Clascá, Francisco Markram, Henry Hill, Sean L. |
author_facet | Iavarone, Elisabetta Simko, Jane Shi, Ying Bertschy, Marine García-Amado, María Litvak, Polina Kaufmann, Anna-Kristin O’Reilly, Christian Amsalem, Oren Abdellah, Marwan Chevtchenko, Grigori Coste, Benoît Courcol, Jean-Denis Ecker, András Favreau, Cyrille Fleury, Adrien Christian Van Geit, Werner Gevaert, Michael Guerrero, Nadir Román Herttuainen, Joni Ivaska, Genrich Kerrien, Samuel King, James G. Kumbhar, Pramod Lurie, Patrycja Magkanaris, Ioannis Muddapu, Vignayanandam Ravindernath Nair, Jayakrishnan Pereira, Fernando L. Perin, Rodrigo Petitjean, Fabien Ranjan, Rajnish Reimann, Michael Soltuzu, Liviu Sy, Mohameth François Tuncel, M. Anıl Ulbrich, Alexander Wolf, Matthias Clascá, Francisco Markram, Henry Hill, Sean L. |
author_sort | Iavarone, Elisabetta |
collection | PubMed |
description | Thalamoreticular circuitry plays a key role in arousal, attention, cognition, and sleep spindles, and is linked to several brain disorders. A detailed computational model of mouse somatosensory thalamus and thalamic reticular nucleus has been developed to capture the properties of over 14,000 neurons connected by 6 million synapses. The model recreates the biological connectivity of these neurons, and simulations of the model reproduce multiple experimental findings in different brain states. The model shows that inhibitory rebound produces frequency-selective enhancement of thalamic responses during wakefulness. We find that thalamic interactions are responsible for the characteristic waxing and waning of spindle oscillations. In addition, we find that changes in thalamic excitability control spindle frequency and their incidence. The model is made openly available to provide a new tool for studying the function and dysfunction of the thalamoreticular circuitry in various brain states. |
format | Online Article Text |
id | pubmed-10066598 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cell Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-100665982023-04-02 Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep Iavarone, Elisabetta Simko, Jane Shi, Ying Bertschy, Marine García-Amado, María Litvak, Polina Kaufmann, Anna-Kristin O’Reilly, Christian Amsalem, Oren Abdellah, Marwan Chevtchenko, Grigori Coste, Benoît Courcol, Jean-Denis Ecker, András Favreau, Cyrille Fleury, Adrien Christian Van Geit, Werner Gevaert, Michael Guerrero, Nadir Román Herttuainen, Joni Ivaska, Genrich Kerrien, Samuel King, James G. Kumbhar, Pramod Lurie, Patrycja Magkanaris, Ioannis Muddapu, Vignayanandam Ravindernath Nair, Jayakrishnan Pereira, Fernando L. Perin, Rodrigo Petitjean, Fabien Ranjan, Rajnish Reimann, Michael Soltuzu, Liviu Sy, Mohameth François Tuncel, M. Anıl Ulbrich, Alexander Wolf, Matthias Clascá, Francisco Markram, Henry Hill, Sean L. Cell Rep Resource Thalamoreticular circuitry plays a key role in arousal, attention, cognition, and sleep spindles, and is linked to several brain disorders. A detailed computational model of mouse somatosensory thalamus and thalamic reticular nucleus has been developed to capture the properties of over 14,000 neurons connected by 6 million synapses. The model recreates the biological connectivity of these neurons, and simulations of the model reproduce multiple experimental findings in different brain states. The model shows that inhibitory rebound produces frequency-selective enhancement of thalamic responses during wakefulness. We find that thalamic interactions are responsible for the characteristic waxing and waning of spindle oscillations. In addition, we find that changes in thalamic excitability control spindle frequency and their incidence. The model is made openly available to provide a new tool for studying the function and dysfunction of the thalamoreticular circuitry in various brain states. Cell Press 2023-03-01 /pmc/articles/PMC10066598/ /pubmed/36867532 http://dx.doi.org/10.1016/j.celrep.2023.112200 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Resource Iavarone, Elisabetta Simko, Jane Shi, Ying Bertschy, Marine García-Amado, María Litvak, Polina Kaufmann, Anna-Kristin O’Reilly, Christian Amsalem, Oren Abdellah, Marwan Chevtchenko, Grigori Coste, Benoît Courcol, Jean-Denis Ecker, András Favreau, Cyrille Fleury, Adrien Christian Van Geit, Werner Gevaert, Michael Guerrero, Nadir Román Herttuainen, Joni Ivaska, Genrich Kerrien, Samuel King, James G. Kumbhar, Pramod Lurie, Patrycja Magkanaris, Ioannis Muddapu, Vignayanandam Ravindernath Nair, Jayakrishnan Pereira, Fernando L. Perin, Rodrigo Petitjean, Fabien Ranjan, Rajnish Reimann, Michael Soltuzu, Liviu Sy, Mohameth François Tuncel, M. Anıl Ulbrich, Alexander Wolf, Matthias Clascá, Francisco Markram, Henry Hill, Sean L. Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep |
title | Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep |
title_full | Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep |
title_fullStr | Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep |
title_full_unstemmed | Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep |
title_short | Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep |
title_sort | thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep |
topic | Resource |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066598/ https://www.ncbi.nlm.nih.gov/pubmed/36867532 http://dx.doi.org/10.1016/j.celrep.2023.112200 |
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