Drug Metabolism and Pharmacokinetics of Antisense Oligonucleotide Therapeutics: Typical Profiles, Evaluation Approaches, and Points to Consider Compared with Small Molecule Drugs

Oligonucleotide therapeutics are attracting attention as a new treatment modality for a range of diseases that have been difficult to target using conventional approaches. Technical advances in chemical modification and drug delivery systems have led to the generation of compounds with excellent pro...

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Detalles Bibliográficos
Autores principales: Takakusa, Hideo, Iwazaki, Norihiko, Nishikawa, Makiya, Yoshida, Tokuyuki, Obika, Satoshi, Inoue, Takao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066781/
https://www.ncbi.nlm.nih.gov/pubmed/36735616
http://dx.doi.org/10.1089/nat.2022.0054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066781/
https://www.ncbi.nlm.nih.gov/pubmed/36735616
http://dx.doi.org/10.1089/nat.2022.0054

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