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A Desmoid Tumor Responding to Systemic Therapy With Tamoxifen and Sulindac

Desmoid tumors are locally aggressive benign tumors arising from connective tissue and are classified as soft tissue sarcomas that do not metastasize. The name is derived from the Greek word desmos that means tendon-like. These tumors are also known as aggressive fibromatosis and have an unpredictab...

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Detalles Bibliográficos
Autores principales: Choudhury, Hasan, Abidoye, Oluseyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066902/
https://www.ncbi.nlm.nih.gov/pubmed/37016646
http://dx.doi.org/10.7759/cureus.35723
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author Choudhury, Hasan
Abidoye, Oluseyi
author_facet Choudhury, Hasan
Abidoye, Oluseyi
author_sort Choudhury, Hasan
collection PubMed
description Desmoid tumors are locally aggressive benign tumors arising from connective tissue and are classified as soft tissue sarcomas that do not metastasize. The name is derived from the Greek word desmos that means tendon-like. These tumors are also known as aggressive fibromatosis and have an unpredictable natural history that varies depending on risk factors. They are treated as sarcomas because of their locally aggressive nature and a high local recurrence rate. The causes behind desmoid tumor development are enigmatic and their clinical course is unpredictable. Disease progression also varies widely depending on multiple syndromic risk factors. At this time, there is no scientific consensus over best treatment practices for this tumor type. Treatment can potentially be a combination of observation, systemic therapy, surgery or radiation therapy. Here, we have described a case of a female patient with a sporadic desmoid tumor that successfully responded to tamoxifen and sulindac.
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spelling pubmed-100669022023-04-03 A Desmoid Tumor Responding to Systemic Therapy With Tamoxifen and Sulindac Choudhury, Hasan Abidoye, Oluseyi Cureus Internal Medicine Desmoid tumors are locally aggressive benign tumors arising from connective tissue and are classified as soft tissue sarcomas that do not metastasize. The name is derived from the Greek word desmos that means tendon-like. These tumors are also known as aggressive fibromatosis and have an unpredictable natural history that varies depending on risk factors. They are treated as sarcomas because of their locally aggressive nature and a high local recurrence rate. The causes behind desmoid tumor development are enigmatic and their clinical course is unpredictable. Disease progression also varies widely depending on multiple syndromic risk factors. At this time, there is no scientific consensus over best treatment practices for this tumor type. Treatment can potentially be a combination of observation, systemic therapy, surgery or radiation therapy. Here, we have described a case of a female patient with a sporadic desmoid tumor that successfully responded to tamoxifen and sulindac. Cureus 2023-03-03 /pmc/articles/PMC10066902/ /pubmed/37016646 http://dx.doi.org/10.7759/cureus.35723 Text en Copyright © 2023, Choudhury et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Choudhury, Hasan
Abidoye, Oluseyi
A Desmoid Tumor Responding to Systemic Therapy With Tamoxifen and Sulindac
title A Desmoid Tumor Responding to Systemic Therapy With Tamoxifen and Sulindac
title_full A Desmoid Tumor Responding to Systemic Therapy With Tamoxifen and Sulindac
title_fullStr A Desmoid Tumor Responding to Systemic Therapy With Tamoxifen and Sulindac
title_full_unstemmed A Desmoid Tumor Responding to Systemic Therapy With Tamoxifen and Sulindac
title_short A Desmoid Tumor Responding to Systemic Therapy With Tamoxifen and Sulindac
title_sort desmoid tumor responding to systemic therapy with tamoxifen and sulindac
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066902/
https://www.ncbi.nlm.nih.gov/pubmed/37016646
http://dx.doi.org/10.7759/cureus.35723
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