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Demographic, clinical and microbiological characteristics of the first 30 human monkeypox confirmed cases attended in a tertiary hospital in Madrid (Spain), during the May-June 2022 international outbreak

The present outbreak of Human Monkeypox (HMPX) that has begun in May 2022 and has spread across all continents in less than two months has qualitative and quantitative characteristics that make it different from the pattern of human disease previously caused by this virus. It has spread with enormou...

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Autores principales: Cobos, Alejandro, Valerio, Maricela, Palomo, María, Adán, Iván, Catalán, Pilar, Veintimilla, Cristina, López-Andújar, Felipe, Rincón, Cristina, Galar, Alicia, Alonso, Roberto, Machado, Marina, Gijón, Paloma, Lois, Teresa Aldámiz-Echevarría, Latorre, Leire Pérez, Diez, Cristina, Fanciulli, Chiara, Santiago, Emilio Bouza, Muñoz, Patricia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedad Española de Quimioterapia 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066919/
https://www.ncbi.nlm.nih.gov/pubmed/36651283
http://dx.doi.org/10.37201/req/112.2022
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author Cobos, Alejandro
Valerio, Maricela
Palomo, María
Adán, Iván
Catalán, Pilar
Veintimilla, Cristina
López-Andújar, Felipe
Rincón, Cristina
Galar, Alicia
Alonso, Roberto
Machado, Marina
Gijón, Paloma
Lois, Teresa Aldámiz-Echevarría
Latorre, Leire Pérez
Diez, Cristina
Fanciulli, Chiara
Santiago, Emilio Bouza
Muñoz, Patricia
author_facet Cobos, Alejandro
Valerio, Maricela
Palomo, María
Adán, Iván
Catalán, Pilar
Veintimilla, Cristina
López-Andújar, Felipe
Rincón, Cristina
Galar, Alicia
Alonso, Roberto
Machado, Marina
Gijón, Paloma
Lois, Teresa Aldámiz-Echevarría
Latorre, Leire Pérez
Diez, Cristina
Fanciulli, Chiara
Santiago, Emilio Bouza
Muñoz, Patricia
author_sort Cobos, Alejandro
collection PubMed
description The present outbreak of Human Monkeypox (HMPX) that has begun in May 2022 and has spread across all continents in less than two months has qualitative and quantitative characteristics that make it different from the pattern of human disease previously caused by this virus. It has spread with enormous ease, affects almost exclusively adults, behaves as a sexually transmitted disease and focuses on very specific groups and transmission conditions. The high incidence in the city of Madrid in males that have sex with males (MSM) has allowed us to observe and report the experience with the first 30 cases diagnosed in our institution. Patients presented with febrile symptoms, genital and paragenital skin lesions reminiscent of smallpox, but less extensive and severe. The disease may also cause proctitis, pharyngitis and perioral lesions. The PCR test for diagnostic confirmation has been shown to be very sensitive and effective, not only in skin lesions but also in blood and other fluids such as pharyngeal, rectal exudates and blood. A very high proportion of patients with HMPX also have other sexually transmitted diseases that must be actively detected in this context. The spontaneous evolution of our patients has been good and hospitalization has been practically unnecessary. Transmission to non-sexual cohabitants and health personnel has been nonexistent and the lesions have disappeared in less than 30 days without leaving sequelae and no need for specific antiviral treatment.
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spelling pubmed-100669192023-04-03 Demographic, clinical and microbiological characteristics of the first 30 human monkeypox confirmed cases attended in a tertiary hospital in Madrid (Spain), during the May-June 2022 international outbreak Cobos, Alejandro Valerio, Maricela Palomo, María Adán, Iván Catalán, Pilar Veintimilla, Cristina López-Andújar, Felipe Rincón, Cristina Galar, Alicia Alonso, Roberto Machado, Marina Gijón, Paloma Lois, Teresa Aldámiz-Echevarría Latorre, Leire Pérez Diez, Cristina Fanciulli, Chiara Santiago, Emilio Bouza Muñoz, Patricia Rev Esp Quimioter Original The present outbreak of Human Monkeypox (HMPX) that has begun in May 2022 and has spread across all continents in less than two months has qualitative and quantitative characteristics that make it different from the pattern of human disease previously caused by this virus. It has spread with enormous ease, affects almost exclusively adults, behaves as a sexually transmitted disease and focuses on very specific groups and transmission conditions. The high incidence in the city of Madrid in males that have sex with males (MSM) has allowed us to observe and report the experience with the first 30 cases diagnosed in our institution. Patients presented with febrile symptoms, genital and paragenital skin lesions reminiscent of smallpox, but less extensive and severe. The disease may also cause proctitis, pharyngitis and perioral lesions. The PCR test for diagnostic confirmation has been shown to be very sensitive and effective, not only in skin lesions but also in blood and other fluids such as pharyngeal, rectal exudates and blood. A very high proportion of patients with HMPX also have other sexually transmitted diseases that must be actively detected in this context. The spontaneous evolution of our patients has been good and hospitalization has been practically unnecessary. Transmission to non-sexual cohabitants and health personnel has been nonexistent and the lesions have disappeared in less than 30 days without leaving sequelae and no need for specific antiviral treatment. Sociedad Española de Quimioterapia 2023-01-18 2023 /pmc/articles/PMC10066919/ /pubmed/36651283 http://dx.doi.org/10.37201/req/112.2022 Text en © The Author 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)(https://creativecommons.org/licenses/by-nc/4.0/).
spellingShingle Original
Cobos, Alejandro
Valerio, Maricela
Palomo, María
Adán, Iván
Catalán, Pilar
Veintimilla, Cristina
López-Andújar, Felipe
Rincón, Cristina
Galar, Alicia
Alonso, Roberto
Machado, Marina
Gijón, Paloma
Lois, Teresa Aldámiz-Echevarría
Latorre, Leire Pérez
Diez, Cristina
Fanciulli, Chiara
Santiago, Emilio Bouza
Muñoz, Patricia
Demographic, clinical and microbiological characteristics of the first 30 human monkeypox confirmed cases attended in a tertiary hospital in Madrid (Spain), during the May-June 2022 international outbreak
title Demographic, clinical and microbiological characteristics of the first 30 human monkeypox confirmed cases attended in a tertiary hospital in Madrid (Spain), during the May-June 2022 international outbreak
title_full Demographic, clinical and microbiological characteristics of the first 30 human monkeypox confirmed cases attended in a tertiary hospital in Madrid (Spain), during the May-June 2022 international outbreak
title_fullStr Demographic, clinical and microbiological characteristics of the first 30 human monkeypox confirmed cases attended in a tertiary hospital in Madrid (Spain), during the May-June 2022 international outbreak
title_full_unstemmed Demographic, clinical and microbiological characteristics of the first 30 human monkeypox confirmed cases attended in a tertiary hospital in Madrid (Spain), during the May-June 2022 international outbreak
title_short Demographic, clinical and microbiological characteristics of the first 30 human monkeypox confirmed cases attended in a tertiary hospital in Madrid (Spain), during the May-June 2022 international outbreak
title_sort demographic, clinical and microbiological characteristics of the first 30 human monkeypox confirmed cases attended in a tertiary hospital in madrid (spain), during the may-june 2022 international outbreak
topic Original
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066919/
https://www.ncbi.nlm.nih.gov/pubmed/36651283
http://dx.doi.org/10.37201/req/112.2022
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