Effect of Famotidine on COVID-19: Killing Virus or Opposing ARDS?

Since the first detection of SARS-CoV-2 in China, COVID-19 (Corona Virus Disease 2019) has taken the lives of more than six million people. Although some antivirals seem proper for treatment, the investigation of finding the best therapeutic approach for COVID-19 is still continuing. Some observatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Hosseini, Mahnaz Sadat, Davoudi-Monfared, Effat, Najmeddin, Farhad, Mojtahedzadeh, Mojtaba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2023
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066957/
https://www.ncbi.nlm.nih.gov/pubmed/37004651
http://dx.doi.org/10.1007/s41030-023-00220-4
_version_ 1785018360714493952
author Hosseini, Mahnaz Sadat
Davoudi-Monfared, Effat
Najmeddin, Farhad
Mojtahedzadeh, Mojtaba
author_facet Hosseini, Mahnaz Sadat
Davoudi-Monfared, Effat
Najmeddin, Farhad
Mojtahedzadeh, Mojtaba
author_sort Hosseini, Mahnaz Sadat
collection PubMed
description Since the first detection of SARS-CoV-2 in China, COVID-19 (Corona Virus Disease 2019) has taken the lives of more than six million people. Although some antivirals seem proper for treatment, the investigation of finding the best therapeutic approach for COVID-19 is still continuing. Some observational research showed that famotidine has promising effects in addition to its acid-suppressing characteristics in the treatment of COVID-19. The definite viricidal effect of famotidine is not established. Opposing acute respiratory distress syndrome (ARDS) can be proposed as a probable mechanism for the action of famotidine, due to its inhibitory effect on histamine release, inhibition of transmembrane protease serine S (TMPRSS) and stabilizing glycocalyx. These hypotheses should be under investigation in the future.
format Online
Article
Text
id pubmed-10066957
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Springer Healthcare
record_format MEDLINE/PubMed
spelling pubmed-100669572023-04-03 Effect of Famotidine on COVID-19: Killing Virus or Opposing ARDS? Hosseini, Mahnaz Sadat Davoudi-Monfared, Effat Najmeddin, Farhad Mojtahedzadeh, Mojtaba Pulm Ther Commentary Since the first detection of SARS-CoV-2 in China, COVID-19 (Corona Virus Disease 2019) has taken the lives of more than six million people. Although some antivirals seem proper for treatment, the investigation of finding the best therapeutic approach for COVID-19 is still continuing. Some observational research showed that famotidine has promising effects in addition to its acid-suppressing characteristics in the treatment of COVID-19. The definite viricidal effect of famotidine is not established. Opposing acute respiratory distress syndrome (ARDS) can be proposed as a probable mechanism for the action of famotidine, due to its inhibitory effect on histamine release, inhibition of transmembrane protease serine S (TMPRSS) and stabilizing glycocalyx. These hypotheses should be under investigation in the future. Springer Healthcare 2023-04-01 /pmc/articles/PMC10066957/ /pubmed/37004651 http://dx.doi.org/10.1007/s41030-023-00220-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Commentary
Hosseini, Mahnaz Sadat
Davoudi-Monfared, Effat
Najmeddin, Farhad
Mojtahedzadeh, Mojtaba
Effect of Famotidine on COVID-19: Killing Virus or Opposing ARDS?
title Effect of Famotidine on COVID-19: Killing Virus or Opposing ARDS?
title_full Effect of Famotidine on COVID-19: Killing Virus or Opposing ARDS?
title_fullStr Effect of Famotidine on COVID-19: Killing Virus or Opposing ARDS?
title_full_unstemmed Effect of Famotidine on COVID-19: Killing Virus or Opposing ARDS?
title_short Effect of Famotidine on COVID-19: Killing Virus or Opposing ARDS?
title_sort effect of famotidine on covid-19: killing virus or opposing ards?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066957/
https://www.ncbi.nlm.nih.gov/pubmed/37004651
http://dx.doi.org/10.1007/s41030-023-00220-4
work_keys_str_mv AT hosseinimahnazsadat effectoffamotidineoncovid19killingvirusoropposingards
AT davoudimonfaredeffat effectoffamotidineoncovid19killingvirusoropposingards
AT najmeddinfarhad effectoffamotidineoncovid19killingvirusoropposingards
AT mojtahedzadehmojtaba effectoffamotidineoncovid19killingvirusoropposingards

Ejemplares similares