Large DNA fragment knock-in and sequential gene editing in Plasmodium falciparum: a preliminary study using suicide-rescue-based CRISPR/Cas9 system

CRISPR/Cas9 technology applied to Plasmodium falciparum offers the potential to greatly improve gene editing, but such expectations including large DNA fragment knock-ins and sequential gene editing have remained unfulfilled. Here, we achieved a major advance in addressing this challenge, especially...

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Detalles Bibliográficos
Autores principales: Lu, Junnan, Tong, Ying, Dong, Rui, Yang, Yijun, Hu, Wen, Zhang, Minghong, Liu, Quan, Zhao, Siting, Adams, John H., Qin, Li, Chen, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066980/
https://www.ncbi.nlm.nih.gov/pubmed/37004637
http://dx.doi.org/10.1007/s11010-023-04711-5

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