Molecular characterization of AML‐MRC reveals TP53 mutation as an adverse prognostic factor irrespective of MRC‐defining criteria, TP53 allelic state, or TP53 variant allele frequency

BACKGROUND: Acute myeloid leukemia with myelodysplasia‐related changes (AML‐MRC) generally confers poor prognosis, however, patient outcomes are heterogeneous. The impact of TP53 allelic state and variant allele frequency (VAF) in AML‐MRC remains poorly defined. METHODS: We retrospectively evaluated...

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Detalles Bibliográficos
Autores principales: Zhao, Davidson, Eladl, Entsar, Zarif, Mojgan, Capo‐Chichi, José‐Mario, Schuh, Andre, Atenafu, Eshetu, Minden, Mark, Chang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
RESEARCH ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067127/
https://www.ncbi.nlm.nih.gov/pubmed/36394085
http://dx.doi.org/10.1002/cam4.5421

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