COVID-19 vaccination for the prevention and treatment of long COVID: A systematic review and meta-analysis

Empirical evidence addressing the association between SARS-CoV-2 vaccination and long COVID would guide public health priorities and inform personal health decisions. Herein, the co-primary objectives are to determine the differential risk of long COVID in vaccinated versus unvaccinated patients, an...

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Detalles Bibliográficos
Autores principales: Ceban, Felicia, Kulzhabayeva, Dana, Rodrigues, Nelson B., Di Vincenzo, Joshua D., Gill, Hartej, Subramaniapillai, Mehala, Lui, Leanna M.W., Cao, Bing, Mansur, Rodrigo B., Ho, Roger C., Burke, Matthew J., Rhee, Taeho Greg, Rosenblat, Joshua D., McIntyre, Roger S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067136/
https://www.ncbi.nlm.nih.gov/pubmed/36990297
http://dx.doi.org/10.1016/j.bbi.2023.03.022
Descripción
Sumario:Empirical evidence addressing the association between SARS-CoV-2 vaccination and long COVID would guide public health priorities and inform personal health decisions. Herein, the co-primary objectives are to determine the differential risk of long COVID in vaccinated versus unvaccinated patients, and the trajectory of long COVID following vaccination. Of 2775 articles identified via systematic search, 17 were included, and 6 were meta-analyzed. Meta-analytic results determined that at least one vaccine dose was associated with a protective effect against long COVID (OR 0.539, 95% CI 0.295–0.987, p = 0.045, N = 257 817). Qualitative analysis revealed that trajectories of pre-existing long COVID following vaccination were mixed, with most patients reporting no changes. The evidence herein supports SARS-CoV-2 vaccination for the prevention of long COVID, and recommends long COVID patients adhere to standard SARS-CoV-2 vaccination schedules.

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