Precise pancreatic cancer therapy through targeted degradation of mutant p53 protein by cerium oxide nanoparticles

BACKGROUND: In a significant proportion of cancers, point mutations of TP53 gene occur within the DNA-binding domain, resulting in an abundance of mutant p53 proteins (mutp53) within cells, which possess tumor-promoting properties. A potential and straightforward strategy for addressing p53-mutated...

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Detalles Bibliográficos
Autores principales: Zhang, Hao, Zhang, Wang, Hu, Bochuan, Qin, Xiaohua, Yi, Tianxiang, Ye, Yayi, Huang, Xiaowan, Song, Yang, Yang, Zhenyu, Qian, Jieying, Zhang, Yunjiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067194/
https://www.ncbi.nlm.nih.gov/pubmed/37005668
http://dx.doi.org/10.1186/s12951-023-01867-6

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