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Polygenic risk score for attention‐deficit/hyperactivity disorder and brain functional networks segregation in a community‐based sample
Neuroimaging studies suggest that brain development mechanisms might explain at least some behavioural and cognitive attention‐deficit/hyperactivity disorder (ADHD) symptoms. However, the putative mechanisms by which genetic susceptibility factors influence clinical features via alterations of brain...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067387/ https://www.ncbi.nlm.nih.gov/pubmed/36811275 http://dx.doi.org/10.1111/gbb.12838 |
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author | Sato, João Ricardo Biazoli, Claudinei Eduardo Bueno, Ana Paula Arantes Caye, Arthur Pan, Pedro Mario Santoro, Marcos Honorato‐Mauer, Jessica Salum, Giovanni Abrahão Hoexter, Marcelo Queiroz Bressan, Rodrigo Affonseca Jackowski, Andrea Parolin Miguel, Euripedes Constantino Belangero, Sintia Rohde, Luis Augusto |
author_facet | Sato, João Ricardo Biazoli, Claudinei Eduardo Bueno, Ana Paula Arantes Caye, Arthur Pan, Pedro Mario Santoro, Marcos Honorato‐Mauer, Jessica Salum, Giovanni Abrahão Hoexter, Marcelo Queiroz Bressan, Rodrigo Affonseca Jackowski, Andrea Parolin Miguel, Euripedes Constantino Belangero, Sintia Rohde, Luis Augusto |
author_sort | Sato, João Ricardo |
collection | PubMed |
description | Neuroimaging studies suggest that brain development mechanisms might explain at least some behavioural and cognitive attention‐deficit/hyperactivity disorder (ADHD) symptoms. However, the putative mechanisms by which genetic susceptibility factors influence clinical features via alterations of brain development remain largely unknown. Here, we set out to integrate genomics and connectomics tools by investigating the associations between an ADHD polygenic risk score (ADHD‐PRS) and functional segregation of large‐scale brain networks. With this aim, ADHD symptoms score, genetic and rs‐fMRI (resting‐state functional magnetic resonance image) data obtained in a longitudinal community‐based cohort of 227 children and adolescents were analysed. A follow‐up was conducted approximately 3 years after the baseline, with rs‐fMRI scanning and ADHD likelihood assessment in both stages. We hypothesised a negative correlation between probable ADHD and the segregation of networks involved in executive functions, and a positive correlation with the default‐mode network (DMN). Our findings suggest that ADHD‐PRS is correlated with ADHD at baseline, but not at follow‐up. Despite not surviving for multiple comparison correction, we found significant correlations between ADHD‐PRS and segregation of cingulo‐opercular networks and DMN at baseline. ADHD‐PRS was negatively correlated with the segregation level of cingulo‐opercular networks but positively correlated with the DMN segregation. These directions of associations corroborate the proposed counter‐balanced role of attentional networks and DMN in attentional processes. However, the association between ADHD‐PRS and brain networks functional segregation was not found at follow‐up. Our results provide evidence for specific influences of genetic factors on development of attentional networks and DMN. We found significant correlations between polygenic risk score for ADHD (ADHD‐PRS) and segregation of cingulo‐opercular networks and default‐mode network (DMN) at baseline. ADHD‐PRS was negatively correlated with the segregation level of cingulo‐opercular networks but positively correlated with the DMN segregation. |
format | Online Article Text |
id | pubmed-10067387 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-100673872023-04-04 Polygenic risk score for attention‐deficit/hyperactivity disorder and brain functional networks segregation in a community‐based sample Sato, João Ricardo Biazoli, Claudinei Eduardo Bueno, Ana Paula Arantes Caye, Arthur Pan, Pedro Mario Santoro, Marcos Honorato‐Mauer, Jessica Salum, Giovanni Abrahão Hoexter, Marcelo Queiroz Bressan, Rodrigo Affonseca Jackowski, Andrea Parolin Miguel, Euripedes Constantino Belangero, Sintia Rohde, Luis Augusto Genes Brain Behav Original Articles Neuroimaging studies suggest that brain development mechanisms might explain at least some behavioural and cognitive attention‐deficit/hyperactivity disorder (ADHD) symptoms. However, the putative mechanisms by which genetic susceptibility factors influence clinical features via alterations of brain development remain largely unknown. Here, we set out to integrate genomics and connectomics tools by investigating the associations between an ADHD polygenic risk score (ADHD‐PRS) and functional segregation of large‐scale brain networks. With this aim, ADHD symptoms score, genetic and rs‐fMRI (resting‐state functional magnetic resonance image) data obtained in a longitudinal community‐based cohort of 227 children and adolescents were analysed. A follow‐up was conducted approximately 3 years after the baseline, with rs‐fMRI scanning and ADHD likelihood assessment in both stages. We hypothesised a negative correlation between probable ADHD and the segregation of networks involved in executive functions, and a positive correlation with the default‐mode network (DMN). Our findings suggest that ADHD‐PRS is correlated with ADHD at baseline, but not at follow‐up. Despite not surviving for multiple comparison correction, we found significant correlations between ADHD‐PRS and segregation of cingulo‐opercular networks and DMN at baseline. ADHD‐PRS was negatively correlated with the segregation level of cingulo‐opercular networks but positively correlated with the DMN segregation. These directions of associations corroborate the proposed counter‐balanced role of attentional networks and DMN in attentional processes. However, the association between ADHD‐PRS and brain networks functional segregation was not found at follow‐up. Our results provide evidence for specific influences of genetic factors on development of attentional networks and DMN. We found significant correlations between polygenic risk score for ADHD (ADHD‐PRS) and segregation of cingulo‐opercular networks and default‐mode network (DMN) at baseline. ADHD‐PRS was negatively correlated with the segregation level of cingulo‐opercular networks but positively correlated with the DMN segregation. Blackwell Publishing Ltd 2023-02-21 /pmc/articles/PMC10067387/ /pubmed/36811275 http://dx.doi.org/10.1111/gbb.12838 Text en © 2023 The Authors. Genes, Brain and Behavior published by International Behavioural and Neural Genetics Society and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Sato, João Ricardo Biazoli, Claudinei Eduardo Bueno, Ana Paula Arantes Caye, Arthur Pan, Pedro Mario Santoro, Marcos Honorato‐Mauer, Jessica Salum, Giovanni Abrahão Hoexter, Marcelo Queiroz Bressan, Rodrigo Affonseca Jackowski, Andrea Parolin Miguel, Euripedes Constantino Belangero, Sintia Rohde, Luis Augusto Polygenic risk score for attention‐deficit/hyperactivity disorder and brain functional networks segregation in a community‐based sample |
title | Polygenic risk score for attention‐deficit/hyperactivity disorder and brain functional networks segregation in a community‐based sample |
title_full | Polygenic risk score for attention‐deficit/hyperactivity disorder and brain functional networks segregation in a community‐based sample |
title_fullStr | Polygenic risk score for attention‐deficit/hyperactivity disorder and brain functional networks segregation in a community‐based sample |
title_full_unstemmed | Polygenic risk score for attention‐deficit/hyperactivity disorder and brain functional networks segregation in a community‐based sample |
title_short | Polygenic risk score for attention‐deficit/hyperactivity disorder and brain functional networks segregation in a community‐based sample |
title_sort | polygenic risk score for attention‐deficit/hyperactivity disorder and brain functional networks segregation in a community‐based sample |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067387/ https://www.ncbi.nlm.nih.gov/pubmed/36811275 http://dx.doi.org/10.1111/gbb.12838 |
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