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Lactic acidosis induces metabolic and phenotypic reprogramming in cholangiocarcinoma cells via the upregulation of thrombospondin‐1

The high glycolytic activity of cancer cells leads to lactic acidosis (LA) in the tumor microenvironment. LA is not merely a consequence of metabolic activities but also has functional roles in metabolic reprogramming and cancer progression. Cholangiocarcinoma (CCA) cells exhibit a high dependency o...

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Detalles Bibliográficos
Autores principales:	Thamrongwaranggoon, Ubonrat, Kuribayashi, Kanji, Araki, Hirotaka, Hino, Yuko, Koga, Tomoaki, Seubwai, Wunchana, Wongkham, Sopit, Nakao, Mitsuyoshi, Hino, Shinjiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	ORIGINAL ARTICLES
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067391/ https://www.ncbi.nlm.nih.gov/pubmed/36562400 http://dx.doi.org/10.1111/cas.15699

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