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Mature dendritic cells enriched in regulatory molecules may control regulatory T cells and the prognosis of head and neck cancer
We previously reported that regulatory T (Treg) cells expressing CTLA‐4 on the cell surface are abundant in head and neck squamous cell carcinoma (HNSCC). The role of expanded Treg cells in the tumor microenvironment of HNSCC remains unclear. In this study, we reveal that the tumor microenvironment...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067395/ https://www.ncbi.nlm.nih.gov/pubmed/36529525 http://dx.doi.org/10.1111/cas.15698 |
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author | Minohara, Kiyoshi Imai, Masaki Matoba, Takuma Wing, James Badger Shime, Hiroaki Odanaka, Mizuyu Uraki, Ryuta Kawakita, Daisuke Toyama, Tatsuya Takahashi, Satoru Morita, Akimichi Murakami, Shingo Ohkura, Naganari Sakaguchi, Shimon Iwasaki, Shinichi Yamazaki, Sayuri |
author_facet | Minohara, Kiyoshi Imai, Masaki Matoba, Takuma Wing, James Badger Shime, Hiroaki Odanaka, Mizuyu Uraki, Ryuta Kawakita, Daisuke Toyama, Tatsuya Takahashi, Satoru Morita, Akimichi Murakami, Shingo Ohkura, Naganari Sakaguchi, Shimon Iwasaki, Shinichi Yamazaki, Sayuri |
author_sort | Minohara, Kiyoshi |
collection | PubMed |
description | We previously reported that regulatory T (Treg) cells expressing CTLA‐4 on the cell surface are abundant in head and neck squamous cell carcinoma (HNSCC). The role of expanded Treg cells in the tumor microenvironment of HNSCC remains unclear. In this study, we reveal that the tumor microenvironment of HNSCC is characterized by the high expression of genes related to Treg cells, dendritic cells (DCs), and interleukin (IL)‐17‐related molecules. Increased expression of IL17A, IL17F, or IL23A contributes to a favorable prognosis of HNSCC. In the tumor microenvironment of HNSCC, IL23A and IL12B are expressed in mature dendritic cells enriched in regulatory molecules (mregDCs). The mregDCs in HNSCC are a migratory and mature phenotype; their signature genes strongly correlate with Treg signature genes in HNSCC. We also observed that IL17A was highly expressed in Th17 cells and exhausted CD8(+) T cells in HNSCC. These data suggest that mregDCs in HNSCC may contribute to the prognosis by balancing Treg cells and effector T cells that produce IL‐17. Targeting mregDCs may be a novel strategy for developing new immune therapies against HNSCC. |
format | Online Article Text |
id | pubmed-10067395 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100673952023-04-04 Mature dendritic cells enriched in regulatory molecules may control regulatory T cells and the prognosis of head and neck cancer Minohara, Kiyoshi Imai, Masaki Matoba, Takuma Wing, James Badger Shime, Hiroaki Odanaka, Mizuyu Uraki, Ryuta Kawakita, Daisuke Toyama, Tatsuya Takahashi, Satoru Morita, Akimichi Murakami, Shingo Ohkura, Naganari Sakaguchi, Shimon Iwasaki, Shinichi Yamazaki, Sayuri Cancer Sci ORIGINAL ARTICLES We previously reported that regulatory T (Treg) cells expressing CTLA‐4 on the cell surface are abundant in head and neck squamous cell carcinoma (HNSCC). The role of expanded Treg cells in the tumor microenvironment of HNSCC remains unclear. In this study, we reveal that the tumor microenvironment of HNSCC is characterized by the high expression of genes related to Treg cells, dendritic cells (DCs), and interleukin (IL)‐17‐related molecules. Increased expression of IL17A, IL17F, or IL23A contributes to a favorable prognosis of HNSCC. In the tumor microenvironment of HNSCC, IL23A and IL12B are expressed in mature dendritic cells enriched in regulatory molecules (mregDCs). The mregDCs in HNSCC are a migratory and mature phenotype; their signature genes strongly correlate with Treg signature genes in HNSCC. We also observed that IL17A was highly expressed in Th17 cells and exhausted CD8(+) T cells in HNSCC. These data suggest that mregDCs in HNSCC may contribute to the prognosis by balancing Treg cells and effector T cells that produce IL‐17. Targeting mregDCs may be a novel strategy for developing new immune therapies against HNSCC. John Wiley and Sons Inc. 2023-01-23 /pmc/articles/PMC10067395/ /pubmed/36529525 http://dx.doi.org/10.1111/cas.15698 Text en © 2022 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | ORIGINAL ARTICLES Minohara, Kiyoshi Imai, Masaki Matoba, Takuma Wing, James Badger Shime, Hiroaki Odanaka, Mizuyu Uraki, Ryuta Kawakita, Daisuke Toyama, Tatsuya Takahashi, Satoru Morita, Akimichi Murakami, Shingo Ohkura, Naganari Sakaguchi, Shimon Iwasaki, Shinichi Yamazaki, Sayuri Mature dendritic cells enriched in regulatory molecules may control regulatory T cells and the prognosis of head and neck cancer |
title | Mature dendritic cells enriched in regulatory molecules may control regulatory T cells and the prognosis of head and neck cancer |
title_full | Mature dendritic cells enriched in regulatory molecules may control regulatory T cells and the prognosis of head and neck cancer |
title_fullStr | Mature dendritic cells enriched in regulatory molecules may control regulatory T cells and the prognosis of head and neck cancer |
title_full_unstemmed | Mature dendritic cells enriched in regulatory molecules may control regulatory T cells and the prognosis of head and neck cancer |
title_short | Mature dendritic cells enriched in regulatory molecules may control regulatory T cells and the prognosis of head and neck cancer |
title_sort | mature dendritic cells enriched in regulatory molecules may control regulatory t cells and the prognosis of head and neck cancer |
topic | ORIGINAL ARTICLES |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067395/ https://www.ncbi.nlm.nih.gov/pubmed/36529525 http://dx.doi.org/10.1111/cas.15698 |
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