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Metabolic adaptations of cancer in extreme tumor microenvironments

Cancer cells are highly heterogeneous to adapt to extreme tumor microenvironments (TMEs). TMEs challenge cancer cells via hypoxia, nutrition starvation, and acidic pH, promoting invasion and metastasis concomitant with genetic, epigenetic, and metabolic alterations. Metabolic adaptation to an extrem...

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Detalles Bibliográficos
Autores principales: Nakahara, Ryuichi, Maeda, Keisuke, Aki, Sho, Osawa, Tsuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067430/
https://www.ncbi.nlm.nih.gov/pubmed/36630222
http://dx.doi.org/10.1111/cas.15722