Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration

AIMS: Genetic hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere protein-encoding genes (i.e. genotype-positive HCM). In an increasing number of patients, HCM occurs in the absence of a mutation (i.e. genotype-negative HCM). Mitochondrial dysfunction is thought to be a key driver...

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Detalles Bibliográficos
Autores principales: Nollet, Edgar E, Duursma, Inez, Rozenbaum, Anastasiya, Eggelbusch, Moritz, Wüst, Rob C I, Schoonvelde, Stephan A C, Michels, Michelle, Jansen, Mark, van der Wel, Nicole N, Bedi, Kenneth C, Margulies, Kenneth B, Nirschl, Jeff, Kuster, Diederik W D, van der Velden, Jolanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067466/
https://www.ncbi.nlm.nih.gov/pubmed/36734059
http://dx.doi.org/10.1093/eurheartj/ehad028

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