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Genome-wide analysis for the melatonin trait associated genes and SNPs in dairy goat (Capra hircus) as the molecular breeding markers
Previous studies have reported that the endogenous melatonin level is positively associated with the quality and yield of milk of cows. In the current study, a total of 34,921 SNPs involving 1,177 genes were identified in dairy goats by using the whole genome resequencing bulked segregant analysis (...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067595/ https://www.ncbi.nlm.nih.gov/pubmed/37021000 http://dx.doi.org/10.3389/fgene.2023.1118367 |
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author | Wu, Hao Yi, Qi Ma, Wenkui Yan, Laiqing Guan, Shengyu Wang, Likai Yang, Guang Tan, Xinxing Ji, Pengyun Liu, Guoshi |
author_facet | Wu, Hao Yi, Qi Ma, Wenkui Yan, Laiqing Guan, Shengyu Wang, Likai Yang, Guang Tan, Xinxing Ji, Pengyun Liu, Guoshi |
author_sort | Wu, Hao |
collection | PubMed |
description | Previous studies have reported that the endogenous melatonin level is positively associated with the quality and yield of milk of cows. In the current study, a total of 34,921 SNPs involving 1,177 genes were identified in dairy goats by using the whole genome resequencing bulked segregant analysis (BSA) analysis. These SNPs have been used to match the melatonin levels of the dairy goats. Among them, 3 SNPs has been identified to significantly correlate with melatonin levels. These 3 SNPs include CC genotype 147316, GG genotype 147379 and CC genotype 1389193 which all locate in the exon regions of ASMT and MT2 genes. Dairy goats with these SNPs have approximately 5-fold-higher melatonin levels in milk and serum than the average melatonin level detected in the current goat population. If the melatonin level impacts the milk production in goats as in cows, the results strongly suggest that these 3 SNPs can serve as the molecular markers to select the goats having the improved milk quality and yield. This is a goal of our future study. |
format | Online Article Text |
id | pubmed-10067595 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100675952023-04-04 Genome-wide analysis for the melatonin trait associated genes and SNPs in dairy goat (Capra hircus) as the molecular breeding markers Wu, Hao Yi, Qi Ma, Wenkui Yan, Laiqing Guan, Shengyu Wang, Likai Yang, Guang Tan, Xinxing Ji, Pengyun Liu, Guoshi Front Genet Genetics Previous studies have reported that the endogenous melatonin level is positively associated with the quality and yield of milk of cows. In the current study, a total of 34,921 SNPs involving 1,177 genes were identified in dairy goats by using the whole genome resequencing bulked segregant analysis (BSA) analysis. These SNPs have been used to match the melatonin levels of the dairy goats. Among them, 3 SNPs has been identified to significantly correlate with melatonin levels. These 3 SNPs include CC genotype 147316, GG genotype 147379 and CC genotype 1389193 which all locate in the exon regions of ASMT and MT2 genes. Dairy goats with these SNPs have approximately 5-fold-higher melatonin levels in milk and serum than the average melatonin level detected in the current goat population. If the melatonin level impacts the milk production in goats as in cows, the results strongly suggest that these 3 SNPs can serve as the molecular markers to select the goats having the improved milk quality and yield. This is a goal of our future study. Frontiers Media S.A. 2023-03-20 /pmc/articles/PMC10067595/ /pubmed/37021000 http://dx.doi.org/10.3389/fgene.2023.1118367 Text en Copyright © 2023 Wu, Yi, Ma, Yan, Guan, Wang, Yang, Tan, Ji and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Wu, Hao Yi, Qi Ma, Wenkui Yan, Laiqing Guan, Shengyu Wang, Likai Yang, Guang Tan, Xinxing Ji, Pengyun Liu, Guoshi Genome-wide analysis for the melatonin trait associated genes and SNPs in dairy goat (Capra hircus) as the molecular breeding markers |
title | Genome-wide analysis for the melatonin trait associated genes and SNPs in dairy goat (Capra hircus) as the molecular breeding markers |
title_full | Genome-wide analysis for the melatonin trait associated genes and SNPs in dairy goat (Capra hircus) as the molecular breeding markers |
title_fullStr | Genome-wide analysis for the melatonin trait associated genes and SNPs in dairy goat (Capra hircus) as the molecular breeding markers |
title_full_unstemmed | Genome-wide analysis for the melatonin trait associated genes and SNPs in dairy goat (Capra hircus) as the molecular breeding markers |
title_short | Genome-wide analysis for the melatonin trait associated genes and SNPs in dairy goat (Capra hircus) as the molecular breeding markers |
title_sort | genome-wide analysis for the melatonin trait associated genes and snps in dairy goat (capra hircus) as the molecular breeding markers |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067595/ https://www.ncbi.nlm.nih.gov/pubmed/37021000 http://dx.doi.org/10.3389/fgene.2023.1118367 |
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