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The role of endothelial TRP channels in age-related vascular cognitive impairment and dementia

Transient receptor potential (TRP) proteins are part of a superfamily of polymodal cation channels that can be activated by mechanical, physical, and chemical stimuli. In the vascular endothelium, TRP channels regulate two fundamental parameters: the membrane potential and the intracellular Ca(2+) c...

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Autores principales: Negri, Sharon, Sanford, Madison, Shi, Helen, Tarantini, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067599/
https://www.ncbi.nlm.nih.gov/pubmed/37020858
http://dx.doi.org/10.3389/fnagi.2023.1149820
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author Negri, Sharon
Sanford, Madison
Shi, Helen
Tarantini, Stefano
author_facet Negri, Sharon
Sanford, Madison
Shi, Helen
Tarantini, Stefano
author_sort Negri, Sharon
collection PubMed
description Transient receptor potential (TRP) proteins are part of a superfamily of polymodal cation channels that can be activated by mechanical, physical, and chemical stimuli. In the vascular endothelium, TRP channels regulate two fundamental parameters: the membrane potential and the intracellular Ca(2+) concentration [(Ca(2+))(i)]. TRP channels are widely expressed in the cerebrovascular endothelium, and are emerging as important mediators of several brain microvascular functions (e.g., neurovascular coupling, endothelial function, and blood–brain barrier permeability), which become impaired with aging. Aging is the most significant risk factor for vascular cognitive impairment (VCI), and the number of individuals affected by VCI is expected to exponentially increase in the coming decades. Yet, there are currently no preventative or therapeutic treatments available against the development and progression of VCI. In this review, we discuss the involvement of endothelial TRP channels in diverse physiological processes in the brain as well as in the pathogenesis of age-related VCI to explore future potential neuroprotective strategies.
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spelling pubmed-100675992023-04-04 The role of endothelial TRP channels in age-related vascular cognitive impairment and dementia Negri, Sharon Sanford, Madison Shi, Helen Tarantini, Stefano Front Aging Neurosci Aging Neuroscience Transient receptor potential (TRP) proteins are part of a superfamily of polymodal cation channels that can be activated by mechanical, physical, and chemical stimuli. In the vascular endothelium, TRP channels regulate two fundamental parameters: the membrane potential and the intracellular Ca(2+) concentration [(Ca(2+))(i)]. TRP channels are widely expressed in the cerebrovascular endothelium, and are emerging as important mediators of several brain microvascular functions (e.g., neurovascular coupling, endothelial function, and blood–brain barrier permeability), which become impaired with aging. Aging is the most significant risk factor for vascular cognitive impairment (VCI), and the number of individuals affected by VCI is expected to exponentially increase in the coming decades. Yet, there are currently no preventative or therapeutic treatments available against the development and progression of VCI. In this review, we discuss the involvement of endothelial TRP channels in diverse physiological processes in the brain as well as in the pathogenesis of age-related VCI to explore future potential neuroprotective strategies. Frontiers Media S.A. 2023-03-20 /pmc/articles/PMC10067599/ /pubmed/37020858 http://dx.doi.org/10.3389/fnagi.2023.1149820 Text en Copyright © 2023 Negri, Sanford, Shi and Tarantini. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging Neuroscience
Negri, Sharon
Sanford, Madison
Shi, Helen
Tarantini, Stefano
The role of endothelial TRP channels in age-related vascular cognitive impairment and dementia
title The role of endothelial TRP channels in age-related vascular cognitive impairment and dementia
title_full The role of endothelial TRP channels in age-related vascular cognitive impairment and dementia
title_fullStr The role of endothelial TRP channels in age-related vascular cognitive impairment and dementia
title_full_unstemmed The role of endothelial TRP channels in age-related vascular cognitive impairment and dementia
title_short The role of endothelial TRP channels in age-related vascular cognitive impairment and dementia
title_sort role of endothelial trp channels in age-related vascular cognitive impairment and dementia
topic Aging Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067599/
https://www.ncbi.nlm.nih.gov/pubmed/37020858
http://dx.doi.org/10.3389/fnagi.2023.1149820
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