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Immunoglobulin a vasculitis with testicular/epididymal involvement in children: A retrospective study of a ten-year period

The clinical characteristics and risk factors for testicular/epididymal involvement in 73 children with immunoglobulin A vasculitis (IgAV) who were admitted to our hospital between January 2012 and November 2022 were reviewed. The demographic data, laboratory parameters, and follow-up data of the pa...

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Autores principales: Hu, Jian-Jun, Zhao, Yao-Wang, Wen, Rong, Luo, Yang-Yang, Zhou, Wei-Guo, Liu, Yu-Hang, Qin, Feng, Liu, Chang, He, Tian-Qu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067670/
https://www.ncbi.nlm.nih.gov/pubmed/37020657
http://dx.doi.org/10.3389/fped.2023.1141118
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author Hu, Jian-Jun
Zhao, Yao-Wang
Wen, Rong
Luo, Yang-Yang
Zhou, Wei-Guo
Liu, Yu-Hang
Qin, Feng
Liu, Chang
He, Tian-Qu
author_facet Hu, Jian-Jun
Zhao, Yao-Wang
Wen, Rong
Luo, Yang-Yang
Zhou, Wei-Guo
Liu, Yu-Hang
Qin, Feng
Liu, Chang
He, Tian-Qu
author_sort Hu, Jian-Jun
collection PubMed
description The clinical characteristics and risk factors for testicular/epididymal involvement in 73 children with immunoglobulin A vasculitis (IgAV) who were admitted to our hospital between January 2012 and November 2022 were reviewed. The demographic data, laboratory parameters, and follow-up data of the patients were compared to those of 146 males without testicular/epididymal involvement. A logistic regression analysis was performed to determine the variables associated with testicular/epididymal involvement. The prevalence of testicular/epididymal involvement among male patients with IgAV was 1.3% (73/5,556). Increased blood flow in the testes and/or epididymis on ultrasound was found in 71 patients. The remaining two patients underwent surgical exploration for loss or reduction of testicular blood flow. One patient underwent orchiectomy for intraoperative confirmation of complete right testicular infarction. Pathological findings revealed IgA immune complex deposition in the testis. Patient age (odds ratio [OR] = 0.792; 95% confidence interval [CI]: 0.682–0.919, p = 0.002), platelet count (OR = 1.011; 95% CI: 1.002–1.020, p = 0.013), and immunoglobulin M (IgM) levels (OR = 0.236; 95% CI: 0.091–0.608, p = 0.003) were strongly associated with the occurrence of testicular/epididymal involvement in IgAV. Therefore, young age, increased platelet count, and low IgM levels in patients with IgAV are potential risk factors for testicular/epididymal involvement. Doppler ultrasound can help differentiate IgAV from acute scrotum. Most patients with testicular/epididymal involvement have good prognoses, although serious complications such as testicular infarction may occur.
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spelling pubmed-100676702023-04-04 Immunoglobulin a vasculitis with testicular/epididymal involvement in children: A retrospective study of a ten-year period Hu, Jian-Jun Zhao, Yao-Wang Wen, Rong Luo, Yang-Yang Zhou, Wei-Guo Liu, Yu-Hang Qin, Feng Liu, Chang He, Tian-Qu Front Pediatr Pediatrics The clinical characteristics and risk factors for testicular/epididymal involvement in 73 children with immunoglobulin A vasculitis (IgAV) who were admitted to our hospital between January 2012 and November 2022 were reviewed. The demographic data, laboratory parameters, and follow-up data of the patients were compared to those of 146 males without testicular/epididymal involvement. A logistic regression analysis was performed to determine the variables associated with testicular/epididymal involvement. The prevalence of testicular/epididymal involvement among male patients with IgAV was 1.3% (73/5,556). Increased blood flow in the testes and/or epididymis on ultrasound was found in 71 patients. The remaining two patients underwent surgical exploration for loss or reduction of testicular blood flow. One patient underwent orchiectomy for intraoperative confirmation of complete right testicular infarction. Pathological findings revealed IgA immune complex deposition in the testis. Patient age (odds ratio [OR] = 0.792; 95% confidence interval [CI]: 0.682–0.919, p = 0.002), platelet count (OR = 1.011; 95% CI: 1.002–1.020, p = 0.013), and immunoglobulin M (IgM) levels (OR = 0.236; 95% CI: 0.091–0.608, p = 0.003) were strongly associated with the occurrence of testicular/epididymal involvement in IgAV. Therefore, young age, increased platelet count, and low IgM levels in patients with IgAV are potential risk factors for testicular/epididymal involvement. Doppler ultrasound can help differentiate IgAV from acute scrotum. Most patients with testicular/epididymal involvement have good prognoses, although serious complications such as testicular infarction may occur. Frontiers Media S.A. 2023-03-20 /pmc/articles/PMC10067670/ /pubmed/37020657 http://dx.doi.org/10.3389/fped.2023.1141118 Text en © 2023 Hu, Zhao, Wen, Luo, Zhou, Liu, Qin, Liu and He. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Hu, Jian-Jun
Zhao, Yao-Wang
Wen, Rong
Luo, Yang-Yang
Zhou, Wei-Guo
Liu, Yu-Hang
Qin, Feng
Liu, Chang
He, Tian-Qu
Immunoglobulin a vasculitis with testicular/epididymal involvement in children: A retrospective study of a ten-year period
title Immunoglobulin a vasculitis with testicular/epididymal involvement in children: A retrospective study of a ten-year period
title_full Immunoglobulin a vasculitis with testicular/epididymal involvement in children: A retrospective study of a ten-year period
title_fullStr Immunoglobulin a vasculitis with testicular/epididymal involvement in children: A retrospective study of a ten-year period
title_full_unstemmed Immunoglobulin a vasculitis with testicular/epididymal involvement in children: A retrospective study of a ten-year period
title_short Immunoglobulin a vasculitis with testicular/epididymal involvement in children: A retrospective study of a ten-year period
title_sort immunoglobulin a vasculitis with testicular/epididymal involvement in children: a retrospective study of a ten-year period
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067670/
https://www.ncbi.nlm.nih.gov/pubmed/37020657
http://dx.doi.org/10.3389/fped.2023.1141118
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