Role of the PADI family in inflammatory autoimmune diseases and cancers: A systematic review

The peptidyl arginine deiminase (PADI) family is a calcium ion-dependent group of isozymes with sequence similarity that catalyze the citrullination of proteins. Histones can serve as the target substrate of PADI family isozymes, and therefore, the PADI family is involved in NETosis and the secretio...

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Detalles Bibliográficos
Autores principales: Zhu, Changhui, Liu, Chunyan, Chai, Zhengbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067674/
https://www.ncbi.nlm.nih.gov/pubmed/37020554
http://dx.doi.org/10.3389/fimmu.2023.1115794
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author Zhu, Changhui
Liu, Chunyan
Chai, Zhengbin
author_facet Zhu, Changhui
Liu, Chunyan
Chai, Zhengbin
author_sort Zhu, Changhui
collection PubMed
description The peptidyl arginine deiminase (PADI) family is a calcium ion-dependent group of isozymes with sequence similarity that catalyze the citrullination of proteins. Histones can serve as the target substrate of PADI family isozymes, and therefore, the PADI family is involved in NETosis and the secretion of inflammatory cytokines. Thus, the PADI family is associated with the development of inflammatory autoimmune diseases and cancer, reproductive development, and other related diseases. In this review, we systematically discuss the role of the PADI family in the pathogenesis of various diseases based on studies from the past decade to provide a reference for future research.
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spelling pubmed-100676742023-04-04 Role of the PADI family in inflammatory autoimmune diseases and cancers: A systematic review Zhu, Changhui Liu, Chunyan Chai, Zhengbin Front Immunol Immunology The peptidyl arginine deiminase (PADI) family is a calcium ion-dependent group of isozymes with sequence similarity that catalyze the citrullination of proteins. Histones can serve as the target substrate of PADI family isozymes, and therefore, the PADI family is involved in NETosis and the secretion of inflammatory cytokines. Thus, the PADI family is associated with the development of inflammatory autoimmune diseases and cancer, reproductive development, and other related diseases. In this review, we systematically discuss the role of the PADI family in the pathogenesis of various diseases based on studies from the past decade to provide a reference for future research. Frontiers Media S.A. 2023-03-20 /pmc/articles/PMC10067674/ /pubmed/37020554 http://dx.doi.org/10.3389/fimmu.2023.1115794 Text en Copyright © 2023 Zhu, Liu and Chai https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhu, Changhui
Liu, Chunyan
Chai, Zhengbin
Role of the PADI family in inflammatory autoimmune diseases and cancers: A systematic review
title Role of the PADI family in inflammatory autoimmune diseases and cancers: A systematic review
title_full Role of the PADI family in inflammatory autoimmune diseases and cancers: A systematic review
title_fullStr Role of the PADI family in inflammatory autoimmune diseases and cancers: A systematic review
title_full_unstemmed Role of the PADI family in inflammatory autoimmune diseases and cancers: A systematic review
title_short Role of the PADI family in inflammatory autoimmune diseases and cancers: A systematic review
title_sort role of the padi family in inflammatory autoimmune diseases and cancers: a systematic review
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067674/
https://www.ncbi.nlm.nih.gov/pubmed/37020554
http://dx.doi.org/10.3389/fimmu.2023.1115794
work_keys_str_mv AT zhuchanghui roleofthepadifamilyininflammatoryautoimmunediseasesandcancersasystematicreview
AT liuchunyan roleofthepadifamilyininflammatoryautoimmunediseasesandcancersasystematicreview
AT chaizhengbin roleofthepadifamilyininflammatoryautoimmunediseasesandcancersasystematicreview

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