Leveraging in vitro and pharmacokinetic models to support bench to bedside investigation of XTMAB-16 as a novel pulmonary sarcoidosis treatment

Background: Sarcoidosis is a chronic, multisystem inflammatory disorder characterized by non-caseating epithelioid granulomas; infiltration of mononuclear cells; and destruction of microarchitecture in the skin, eye, heart, and central nervous system, and the lung in >90% of cases. XTMAB-16 is a...

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Detalles Bibliográficos
Autores principales: Offman, Elliot, Singh, Noopur, Julian, Mark W., Locke, Landon W., Bicer, Sabahattin, Mitchell, Jonah, Matthews, Thomas, Anderson, Kirsten, Crouser, Elliott D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067675/
https://www.ncbi.nlm.nih.gov/pubmed/37021060
http://dx.doi.org/10.3389/fphar.2023.1066454

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