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Recurrent Respiratory Papillomatosis (RRP)—Meta-analyses on the use of the HPV vaccine as adjuvant therapy

Recurrent Respiratory Papillomatosis(RRP) is a rare disease with severe morbidity. Treatment is surgical. Prevailing viewpoint is that prophylactic HPV vaccines do not have therapeutic benefit due to their modus operandi. Studies on HPV vaccination alongside surgery were meta-analysed to test effect...

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Autores principales: Goon, Peter, Sauzet, Odile, Schuermann, Matthias, Oppel, Felix, Shao, SenYao, Scholtz, Lars-Uwe, Sudhoff, Holger, Goerner, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067830/
https://www.ncbi.nlm.nih.gov/pubmed/37005390
http://dx.doi.org/10.1038/s41541-023-00644-8
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author Goon, Peter
Sauzet, Odile
Schuermann, Matthias
Oppel, Felix
Shao, SenYao
Scholtz, Lars-Uwe
Sudhoff, Holger
Goerner, Martin
author_facet Goon, Peter
Sauzet, Odile
Schuermann, Matthias
Oppel, Felix
Shao, SenYao
Scholtz, Lars-Uwe
Sudhoff, Holger
Goerner, Martin
author_sort Goon, Peter
collection PubMed
description Recurrent Respiratory Papillomatosis(RRP) is a rare disease with severe morbidity. Treatment is surgical. Prevailing viewpoint is that prophylactic HPV vaccines do not have therapeutic benefit due to their modus operandi. Studies on HPV vaccination alongside surgery were meta-analysed to test effect on burden of disease. Databases were accessed Nov and Dec 2021 [PubMed, Cochrane, Embase and Web of Science]. Main outcome measured was: Mean paired differences in the number of surgeries or recurrences per month. Analyses was performed using: Random effect maximal likelihood estimation model using the Stata module Mataan(StataCorp. 2019. Stata Statistical Software: Release 16. College Station, TX:StataCorp LLC.) Our results found n = 38 patients, suitable for syntheses with one previous meta-analyses (4 published, 2 unpublished studies) n = 63, total of n = 101 patients. Analyses rendered an overall reduction of 0.123 recurrences or surgeries per month (95% confidence interval [0.064, 0.183]). Our meta-analyses concludes that HPV vaccine is a beneficial adjunct therapy alongside surgery
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spelling pubmed-100678302023-04-04 Recurrent Respiratory Papillomatosis (RRP)—Meta-analyses on the use of the HPV vaccine as adjuvant therapy Goon, Peter Sauzet, Odile Schuermann, Matthias Oppel, Felix Shao, SenYao Scholtz, Lars-Uwe Sudhoff, Holger Goerner, Martin NPJ Vaccines Article Recurrent Respiratory Papillomatosis(RRP) is a rare disease with severe morbidity. Treatment is surgical. Prevailing viewpoint is that prophylactic HPV vaccines do not have therapeutic benefit due to their modus operandi. Studies on HPV vaccination alongside surgery were meta-analysed to test effect on burden of disease. Databases were accessed Nov and Dec 2021 [PubMed, Cochrane, Embase and Web of Science]. Main outcome measured was: Mean paired differences in the number of surgeries or recurrences per month. Analyses was performed using: Random effect maximal likelihood estimation model using the Stata module Mataan(StataCorp. 2019. Stata Statistical Software: Release 16. College Station, TX:StataCorp LLC.) Our results found n = 38 patients, suitable for syntheses with one previous meta-analyses (4 published, 2 unpublished studies) n = 63, total of n = 101 patients. Analyses rendered an overall reduction of 0.123 recurrences or surgeries per month (95% confidence interval [0.064, 0.183]). Our meta-analyses concludes that HPV vaccine is a beneficial adjunct therapy alongside surgery Nature Publishing Group UK 2023-04-01 /pmc/articles/PMC10067830/ /pubmed/37005390 http://dx.doi.org/10.1038/s41541-023-00644-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Goon, Peter
Sauzet, Odile
Schuermann, Matthias
Oppel, Felix
Shao, SenYao
Scholtz, Lars-Uwe
Sudhoff, Holger
Goerner, Martin
Recurrent Respiratory Papillomatosis (RRP)—Meta-analyses on the use of the HPV vaccine as adjuvant therapy
title Recurrent Respiratory Papillomatosis (RRP)—Meta-analyses on the use of the HPV vaccine as adjuvant therapy
title_full Recurrent Respiratory Papillomatosis (RRP)—Meta-analyses on the use of the HPV vaccine as adjuvant therapy
title_fullStr Recurrent Respiratory Papillomatosis (RRP)—Meta-analyses on the use of the HPV vaccine as adjuvant therapy
title_full_unstemmed Recurrent Respiratory Papillomatosis (RRP)—Meta-analyses on the use of the HPV vaccine as adjuvant therapy
title_short Recurrent Respiratory Papillomatosis (RRP)—Meta-analyses on the use of the HPV vaccine as adjuvant therapy
title_sort recurrent respiratory papillomatosis (rrp)—meta-analyses on the use of the hpv vaccine as adjuvant therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067830/
https://www.ncbi.nlm.nih.gov/pubmed/37005390
http://dx.doi.org/10.1038/s41541-023-00644-8
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