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The kidney, volume homeostasis and osmoregulation in space: current perspective and knowledge gaps
Although we have sent humans into space for more than 50 years crucial questions regarding kidney physiology, volume regulation and osmoregulation remain unanswered. The complex interactions between the renin-angiotensin-aldosterone system, the sympathetic nervous system, osmoregulatory responses, g...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067832/ https://www.ncbi.nlm.nih.gov/pubmed/37005397 http://dx.doi.org/10.1038/s41526-023-00268-1 |
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author | Olde Engberink, Rik H. G. van Oosten, Paula J. Weber, Tobias Tabury, Kevin Baatout, Sarah Siew, Keith Walsh, Stephen B. Valenti, Giovanna Chouker, Alexander Boutouyrie, Pierre Heer, Martina Jordan, Jens Goswami, Nandu |
author_facet | Olde Engberink, Rik H. G. van Oosten, Paula J. Weber, Tobias Tabury, Kevin Baatout, Sarah Siew, Keith Walsh, Stephen B. Valenti, Giovanna Chouker, Alexander Boutouyrie, Pierre Heer, Martina Jordan, Jens Goswami, Nandu |
author_sort | Olde Engberink, Rik H. G. |
collection | PubMed |
description | Although we have sent humans into space for more than 50 years crucial questions regarding kidney physiology, volume regulation and osmoregulation remain unanswered. The complex interactions between the renin-angiotensin-aldosterone system, the sympathetic nervous system, osmoregulatory responses, glomerular function, tubular function, and environmental factors such as sodium and water intake, motion sickness and ambient temperature make it difficult to establish the exact effect of microgravity and the subsequent fluid shifts and muscle mass loss on these parameters. Unfortunately, not all responses to actual microgravity can be reproduced with head-down tilt bed rest studies, which complicates research on Earth. Better understanding of the effects of microgravity on kidney function, volume regulation and osmoregulation are needed with the advent of long-term deep space missions and planetary surface explorations during which orthostatic intolerance complaints or kidney stone formation can be life-threatening for astronauts. Galactic cosmic radiation may be a new threat to kidney function. In this review, we summarise and highlight the current understandings of the effects of microgravity on kidney function, volume regulation and osmoregulation and discuss knowledge gaps that future studies should address. |
format | Online Article Text |
id | pubmed-10067832 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-100678322023-04-04 The kidney, volume homeostasis and osmoregulation in space: current perspective and knowledge gaps Olde Engberink, Rik H. G. van Oosten, Paula J. Weber, Tobias Tabury, Kevin Baatout, Sarah Siew, Keith Walsh, Stephen B. Valenti, Giovanna Chouker, Alexander Boutouyrie, Pierre Heer, Martina Jordan, Jens Goswami, Nandu NPJ Microgravity Review Article Although we have sent humans into space for more than 50 years crucial questions regarding kidney physiology, volume regulation and osmoregulation remain unanswered. The complex interactions between the renin-angiotensin-aldosterone system, the sympathetic nervous system, osmoregulatory responses, glomerular function, tubular function, and environmental factors such as sodium and water intake, motion sickness and ambient temperature make it difficult to establish the exact effect of microgravity and the subsequent fluid shifts and muscle mass loss on these parameters. Unfortunately, not all responses to actual microgravity can be reproduced with head-down tilt bed rest studies, which complicates research on Earth. Better understanding of the effects of microgravity on kidney function, volume regulation and osmoregulation are needed with the advent of long-term deep space missions and planetary surface explorations during which orthostatic intolerance complaints or kidney stone formation can be life-threatening for astronauts. Galactic cosmic radiation may be a new threat to kidney function. In this review, we summarise and highlight the current understandings of the effects of microgravity on kidney function, volume regulation and osmoregulation and discuss knowledge gaps that future studies should address. Nature Publishing Group UK 2023-04-01 /pmc/articles/PMC10067832/ /pubmed/37005397 http://dx.doi.org/10.1038/s41526-023-00268-1 Text en © The Author(s) 2023, corrected publication 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article Olde Engberink, Rik H. G. van Oosten, Paula J. Weber, Tobias Tabury, Kevin Baatout, Sarah Siew, Keith Walsh, Stephen B. Valenti, Giovanna Chouker, Alexander Boutouyrie, Pierre Heer, Martina Jordan, Jens Goswami, Nandu The kidney, volume homeostasis and osmoregulation in space: current perspective and knowledge gaps |
title | The kidney, volume homeostasis and osmoregulation in space: current perspective and knowledge gaps |
title_full | The kidney, volume homeostasis and osmoregulation in space: current perspective and knowledge gaps |
title_fullStr | The kidney, volume homeostasis and osmoregulation in space: current perspective and knowledge gaps |
title_full_unstemmed | The kidney, volume homeostasis and osmoregulation in space: current perspective and knowledge gaps |
title_short | The kidney, volume homeostasis and osmoregulation in space: current perspective and knowledge gaps |
title_sort | kidney, volume homeostasis and osmoregulation in space: current perspective and knowledge gaps |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067832/ https://www.ncbi.nlm.nih.gov/pubmed/37005397 http://dx.doi.org/10.1038/s41526-023-00268-1 |
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