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Disruption of endosomal trafficking with EGA alters TLR9 cytokine response in human plasmacytoid dendritic cells

Plasmacytoid dendritic cells (pDCs) exhibit bifurcated cytokine responses to TLR9 agonists, an IRF7-mediated type 1 IFN response or a pro-inflammatory cytokine response via the activation of NF-κB. This bifurcated response has been hypothesized to result from either distinct signaling endosomes or e...

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Detalles Bibliográficos
Autores principales:	Wiest, Matthew J., Gu, Chao, Ham, Hyoungjun, Gorvel, Laurent, Keddis, Mira T., Griffing, Leroy W., Joo, HyeMee, Gorvel, Jean-Pierre, Billadeau, Daniel D., Oh, SangKon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067882/ https://www.ncbi.nlm.nih.gov/pubmed/37020542 http://dx.doi.org/10.3389/fimmu.2023.1144127

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