The PTP1B inhibitor MSI-1436 ameliorates liver insulin sensitivity by modulating autophagy, ER stress and systemic inflammation in Equine metabolic syndrome affected horses

BACKGROUND: Equine metabolic syndrome (EMS) is a multifactorial pathology gathering insulin resistance, low-grade inflammation and past or chronic laminitis. Among the several molecular mechanisms underlying EMS pathogenesis, increased negative insulin signalling regulation mediated by protein tyros...

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Detalles Bibliográficos
Autores principales: Bourebaba, Lynda, Serwotka-Suszczak, Anna, Pielok, Ariadna, Sikora, Mateusz, Mularczyk, Malwina, Marycz, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067883/
https://www.ncbi.nlm.nih.gov/pubmed/37020593
http://dx.doi.org/10.3389/fendo.2023.1149610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067883/
https://www.ncbi.nlm.nih.gov/pubmed/37020593
http://dx.doi.org/10.3389/fendo.2023.1149610

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